Yamamoto T, Ohtori S, Chiba T
Department of Anesthesiology, School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, Japan.
Neurosci Lett. 2000 Apr 28;284(3):155-8. doi: 10.1016/s0304-3940(00)01003-x.
Nociceptin, an opioid receptor-like 1 receptor agonist, has been reported to produce an analgesic effect in the rat formalin test. The authors examined the effect of 17 nmol of nociceptin on the expression of Fos-like immunoreactivity (Fos-LI) in the spinal dorsal horn induced by paw formalin injection and compared the effect of 17 nmol of nociceptin with that of equiantinociceptive dose (3 nmol) of morphine. Nociceptin and morphine were administered intrathecally 10 min before the formalin injection and the expression of Fos-LI was examined 2.5 h after the formalin injection. Both 17 nmol of nociceptin and 3 nmol of morphine suppressed the expression of Fos-LI in laminae I-II, but not in laminae III-V, to the same extent. These data suggest that intratheally administered nociceptin and morphine suppress the nociceptive input into the laminae I-II and produce antinociceptive effect.
痛敏肽，一种阿片受体样1受体激动剂，据报道在大鼠福尔马林试验中可产生镇痛作用。作者研究了17纳摩尔痛敏肽对爪部注射福尔马林诱导的脊髓背角中Fos样免疫反应性（Fos-LI）表达的影响，并将17纳摩尔痛敏肽的作用与等效镇痛剂量（3纳摩尔）吗啡的作用进行了比较。在福尔马林注射前10分钟鞘内注射痛敏肽和吗啡，在福尔马林注射后2.5小时检测Fos-LI的表达。17纳摩尔痛敏肽和3纳摩尔吗啡均同等程度地抑制了I-II层而非III-V层中Fos-LI的表达。这些数据表明，鞘内注射痛敏肽和吗啡可抑制向I-II层的伤害性传入并产生镇痛作用。
