Erb K, Liebel J T, Tegeder I, Zeilhofer H U, Brune K, Geisslinger G
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nürnberg, Germany.
Neuroreport. 1997 May 27;8(8):1967-70. doi: 10.1097/00001756-199705260-00034.
The aims of this study were to investigate the dose-dependent effects of spinally delivered nociceptin (0.3, 1, 3.3 and 10 nmol) on flinching behaviour in the rat formalin test and whether these effects were influenced by the concomitant systemic administration of naloxone (3 mg/kg, i.p.). The effect of the highest nociceptin dose differed statistically from vehicle, 0.3 and 1 nmol nociceptin. Following the administration of 1, 3.3 or 10 nmol nociceptin mean total flinches decreased dose-dependently. The effects of 10 nmol nociceptin were not reversed by a high dose of naloxone. We observed a decrease in flinching behaviour with intrathecally to the lumbar enlargement delivered nociceptin and conclude that nociceptin has antinociceptive effects in the rat formalin test.
本研究的目的是探讨经脊髓给予不同剂量的孤啡肽（0.3、1、3.3和10纳摩尔）对大鼠福尔马林试验中退缩行为的剂量依赖性影响，以及这些影响是否受到腹腔注射纳洛酮（3毫克/千克）的影响。最高剂量孤啡肽的作用与溶剂对照组、0.3和1纳摩尔孤啡肽在统计学上存在差异。给予1、3.3或10纳摩尔孤啡肽后，平均总退缩次数呈剂量依赖性减少。高剂量纳洛酮并未逆转10纳摩尔孤啡肽的作用。我们观察到经腰膨大鞘内注射孤啡肽后退缩行为减少，并得出结论：孤啡肽在大鼠福尔马林试验中具有抗伤害感受作用。
