用乙磺半胱氨酸戊烷脒治疗东半球皮肤利什曼病。对11例患者的开放性研究。
Treatment of Old World cutaneous leishmaniasis by pentamidine isethionate. An open study of 11 patients.
作者信息
Hellier I, Dereure O, Tournillac I, Pratlong F, Guillot B, Dedet J P, Guilhou J J
机构信息
Department of Dermatology-Phlebology, CHRU Montpellier, France.
出版信息
Dermatology. 2000;200(2):120-3. doi: 10.1159/000018343.
BACKGROUND
Pentavalent antimonial derivatives (PAD), especially meglumine antimoniate (Glucantime((R))), are usually considered as the first-line drugs for Old World leishmaniasis, but their potential toxicity and the number of required injection, either intralesional or intramuscular, prompt to search for alternative treatments.
OBJECTIVE
To evaluate the efficiency and tolerance of pentamidine isethionate in Old World leishmaniasis.
METHODS
An open pilot study included 11 patients from two regional academic centers, with varied parasitological forms of Old World leishmaniasis, treated with three strictly intramuscular injections of 4 mg/kg of base-pentamidine every other day.
RESULTS
Tolerance was good overall, and 8/11 (73%) of patients responded well with a quick healing of their lesions, little scarring and no relapse.
CONCLUSION
Pentamidine isethionate is a safe and effective first-line treatment for Old World leishmaniasis. Larger-scale prospective studies comparing several dosage regimens of pentamidine and pentamidine isethionate to PAD are warranted.
背景
五价锑衍生物（PAD），尤其是葡甲胺锑酸盐（葡醛锑胺（商标名）），通常被视为治疗旧大陆利什曼病的一线药物，但其潜在毒性以及病灶内或肌肉注射所需的注射次数促使人们寻找替代治疗方法。
目的
评估乙磺半胱氨酸喷他脒治疗旧大陆利什曼病的疗效和耐受性。
方法
一项开放性试点研究纳入了来自两个地区学术中心的11名患者，他们患有不同寄生虫学形式的旧大陆利什曼病，每隔一天接受三次4mg/kg碱式喷他脒的严格肌肉注射治疗。
结果
总体耐受性良好，11名患者中有8名（73%）反应良好，病灶迅速愈合，几乎没有瘢痕形成且无复发。
结论
乙磺半胱氨酸喷他脒是治疗旧大陆利什曼病的一种安全有效的一线治疗方法。有必要开展更大规模的前瞻性研究，比较喷他脒和乙磺半胱氨酸喷他脒与五价锑衍生物的几种给药方案。
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