Montilla P, Túnez I, Muñoz M C, Delgado M J, Salcedo M
Department of Biochemistry and Molecular Biology, University of Cordoba, Spain.
Nephron. 2000 May;85(1):65-70. doi: 10.1159/000045632.
The present study in rats evaluates the effects of the ovariectomy (OVX) with and without the simultaneous administration of 17beta-estradiol (17betaE(2)) on oxidative stress and hyperlipidemic nephropathy induced by a single high dose of adriamycin (AD). OVX enhances oxidative stress and worsens nephropathy induced by AD. These changes are prevented by simultaneous administration of 17betaE(2). OVX alone induced oxidative stress and hyperlipidemia without biochemical evidence of renal dysfunction. Our results revealed that ovarian hormones, especially estrogens, have a protective effect against oxidative stress and nephropathy induced by AD. Since the reactive oxygen species plays a role in the pathogenesis of renal lesion, it is important to emphasize that estrogens and their hydroxylated compounds function as biological antioxidants.
本研究在大鼠中评估了卵巢切除术（OVX）以及同时给予17β-雌二醇（17βE₂）对单次高剂量阿霉素（AD）诱导的氧化应激和高脂血症性肾病的影响。卵巢切除术会增强氧化应激并使阿霉素诱导的肾病恶化。同时给予17βE₂可预防这些变化。单独的卵巢切除术会诱导氧化应激和高脂血症，但无肾功能障碍的生化证据。我们的结果表明，卵巢激素，尤其是雌激素，对阿霉素诱导的氧化应激和肾病具有保护作用。由于活性氧在肾损伤的发病机制中起作用，因此必须强调雌激素及其羟基化化合物具有生物抗氧化剂的功能。
