Pilch H, Schäffer U, Schlenger K, Hawighorst H, Tanner B, Bahlmann F, Höckel M, Kanpstein P G
Clinique obstétricale et gynécologique de l'université Johannes Gutenberg, Mainz, Allemagne.
Gynecol Obstet Fertil. 2000 Jan;28(1):29-37.
Angiogenesis is a factor of spread and metastatization. This fact has been established for many malignancies, but the data concerning cervical cancer are rather conflicting. In a study including 42 patients affected by cervical cancer stages IB to IVA, the authors assess the mean capillary density and the correlations between this parameter and the other anatomoclinical parameters: the VEGF expression, tumoral oxygenation and the data obtained from dynamic MRI. The histologic assessment of the capillary density and the data obtained by dynamic MRI enable us at the same time to quantify the tumoral angiogenesis and establish the prognosis. The two methods could be used routinely as markers of prognosis. VGEF surely plays a role in angiogenesis linked with cervical cancer growth, but its regulation is not definitively clear at the moment. The impact of tumoral oxygenation (whose place as a prognostic marker is clearly established) on tumoral angiogenesis and vessels' permeability as well as its control is currently not clearly established. Further studies on larger populations are necessary.
血管生成是肿瘤扩散和转移的一个因素。这一事实已在多种恶性肿瘤中得到证实，但关于宫颈癌的数据却相当矛盾。在一项纳入42例IB至IVA期宫颈癌患者的研究中，作者评估了平均微血管密度以及该参数与其他解剖临床参数之间的相关性：血管内皮生长因子（VEGF）表达、肿瘤氧合情况以及动态磁共振成像（MRI）获得的数据。微血管密度的组织学评估以及动态MRI获得的数据使我们能够同时量化肿瘤血管生成并确定预后。这两种方法可常规用作预后标志物。VGEF肯定在与宫颈癌生长相关的血管生成中起作用，但目前其调节机制尚不完全清楚。肿瘤氧合（其作为预后标志物的地位已明确确立）对肿瘤血管生成和血管通透性的影响及其调控目前尚不清楚。有必要对更多人群进行进一步研究。
