[伴有自身免疫性溶血性贫血的 CD16+ CD56- 惰性、NK 细胞系颗粒淋巴细胞增殖性疾病]
[CD16+ CD56- indolent, NK cell-lineage granular lymphocyte proliferative disorder with autoimmune hemolytic anemia].
作者信息
Tomita N, Motomura S, Takemura S, Fujimaki K, Sakai R, Harano H, Ishigatsubo Y
机构信息
Department of Hematology, Yokohama City University Medical Center.
出版信息
Rinsho Ketsueki. 2000 Mar;41(3):225-8.
A 64-year-old man was given a diagnosis of CD16+ CD56- natural killer cell-lineage granular lymphocyte proliferative disorder (NK-GLPD) with Coombs-negative autoimmune hemolytic anemia (AIHA). Two courses of 1,000 mg intravenous methylprednisolone for 3 days were transiently effective for both AIHA and NK-GLPD. On the recurrence of AIHA, NK-GLPD also re-appeared. The same treatment was effective in controlling both diseases again. This was a rare case of NK-GLPD combined with autoimmune disease.
一名64岁男性被诊断为CD16+ CD56-自然杀伤细胞系颗粒淋巴细胞增殖性疾病（NK-GLPD），伴有库姆斯试验阴性的自身免疫性溶血性贫血（AIHA）。给予两疗程、为期3天、每次1000毫克的静脉注射甲泼尼龙，对AIHA和NK-GLPD均有短暂疗效。AIHA复发时，NK-GLPD也再次出现。相同治疗再次有效控制了两种疾病。这是一例罕见的NK-GLPD合并自身免疫性疾病的病例。
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