Ha S D, Kataoka H, Suzuki A, Kim B J, Kim H J, Hwang S H, Kong J Y
Faculty of Food Science and Biotechnology, Pukyong National University, Pusan, Korea.
Mol Cells. 2000 Feb 29;10(1):13-7. doi: 10.1007/s10059-000-0013-9.
The insect diuretic hormone (DH) binds to their receptor in malpighian tubules, and stimulates water secretion and cAMP synthesis. Complementary DNA encoding a diuretic hormone receptor was cloned from the malpighian tubules of Bombyx mori. The cloned cDNA encodes a protein consisting of 391 amino acid residues with the seven transmembrane domains. The receptor protein is homologous with that of other insects, and is structurally related to G-protein coupled receptors such as corticotropin relating factor (CRF), secretin, and vasoactive intestinal peptide.
昆虫利尿激素（DH）与其在马氏管中的受体结合，并刺激水分分泌和环磷酸腺苷（cAMP）合成。从家蚕的马氏管中克隆出了编码利尿激素受体的互补DNA。克隆的cDNA编码一种由391个氨基酸残基组成的蛋白质，具有七个跨膜结构域。该受体蛋白与其他昆虫的受体蛋白同源，并且在结构上与促肾上腺皮质激素释放因子（CRF）、促胰液素和血管活性肠肽等G蛋白偶联受体相关。
