Nair R H, Kesavachandran C, Shashidhar S
Physiological Chemistry Research Laboratory, School of Biosciences, Mahatma Gandhi University, Kottayam.
Indian J Physiol Pharmacol. 1999 Oct;43(4):467-73.
The present study elucidates the effect of undernutrition on pulmonary functions in children. The study was carried out in healthy normals, wasted, wasted and stunted children. Spirometry was performed with Vitalograph Compact-II spirometer. Wasted, wasted and stunted children showed lower lung volumes, forced mid expiratory flow time and inspiratory flow rates than healthy normals. Wasted and stunted children had lower VC, FVC and FIF50% than wasted children. The reduction in lung volumes and flow rates in wasted children may be due to ventilatory muscle wasting. But in wasted and stunted children along with muscular wasting diminished skeletal growth is also a reason for lower lung functions. No airflow limitation was observed in undernourished children.
本研究阐明了营养不良对儿童肺功能的影响。该研究在健康正常儿童、消瘦儿童、消瘦且发育迟缓儿童中进行。使用维托拉夫Compact-II肺活量计进行肺功能测定。消瘦儿童、消瘦且发育迟缓儿童的肺容量、用力呼气中期流速和吸气流速均低于健康正常儿童。消瘦且发育迟缓儿童的肺活量、用力肺活量和50%用力吸气流量低于单纯消瘦儿童。消瘦儿童肺容量和流速的降低可能是由于呼吸肌萎缩。但在消瘦且发育迟缓儿童中,除了肌肉萎缩外,骨骼生长受限也是肺功能降低的一个原因。营养不良儿童未观察到气流受限。