Gessner A, Röllinghoff M
Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen-Nürnberg, Germany.
Immunobiology. 2000 Jan;201(3-4):285-307. doi: 10.1016/S0171-2985(00)80084-4.
IL-4 is a pleiotropic cytokine which plays a pivotal role in shaping immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. This review will summarize the current knowledge on the molecular structure of the different types of IL-4 receptor (IL-4R) complexes as well as the signal transduction mechanisms induced by IL-4 leading to cellular proliferation and / or gene activation. IL-4 effects are modulated by soluble forms of the respective receptor molecules which are produced by several immune cells in a regulated manner. The biological impact of recently described IL-4R allotypes of mice and humans as well as the results of studies with IL-4R knockout mice will be particularly emphasized.
白细胞介素-4是一种多效性细胞因子，在塑造免疫反应中起关键作用。白细胞介素-4与造血细胞和非造血细胞上存在的高亲和力受体复合物结合后介导其效应。本综述将总结关于不同类型白细胞介素-4受体（IL-4R）复合物分子结构的当前知识，以及白细胞介素-4诱导的导致细胞增殖和/或基因激活的信号转导机制。白细胞介素-4的效应受到各自受体分子可溶性形式的调节，这些可溶性形式由几种免疫细胞以受调控的方式产生。将特别强调最近描述的小鼠和人类白细胞介素-4R同种异型的生物学影响以及白细胞介素-4R基因敲除小鼠的研究结果。
