Keselman A, Martínez A, Pantano L, Bergadá C, Heinrich J J
CEDIE and Division of Endocrinology, Ricardo Gutiérrez Children's Hospital, Buenos Aires, Argentina.
J Pediatr Endocrinol Metab. 2000 Apr;13(4):409-16. doi: 10.1515/jpem.2000.13.4.409.
Social disabilities have been described in GHD patients. The aim of this study was to evaluate the social outcome of a group of adult hypopituitary patients diagnosed and treated during childhood. Seventy patients were interviewed at a mean age of 25.6 years (range 18-50 yr). They answered a semistructured questionnaire and the Beck Depression Inventory test. Patients were compared for academic achievement, marital status and employment with the nearest age sibling. We found high levels of school repeaters, school was often not completed, and around 50% were overprotected by teachers and teased by peers. 32% were unemployed, while 58% of those employed work with their families. 80% still live with their parents; only 16% are married and 9% have children. 44% had no dating experience and 52% had never had sexual intercourse. Depression was common, especially in hypogonadic subjects. Juvenilization was the most common complaint. We did not found differences in maximal educational achievements and levels of employment between patients and siblings, but significantly more married siblings were found. Depression, social isolation and dependent life style were found in GHD patients. Appropriate medical and psychological counseling should be included for patients and their families as part of treatment.
生长激素缺乏症（GHD）患者存在社交障碍。本研究的目的是评估一组童年期被诊断并接受治疗的成年垂体功能减退患者的社会结局。对70名患者进行了访谈，平均年龄为25.6岁（范围18 - 50岁）。他们回答了一份半结构化问卷和贝克抑郁量表测试。将患者的学业成绩、婚姻状况和就业情况与年龄最接近的兄弟姐妹进行比较。我们发现留级生比例很高，很多人未完成学业，约50%的人受到老师过度保护且被同龄人取笑。32%的人失业，而就业的人中有58%与家人一起工作。80%的人仍与父母同住；只有16%的人结婚，9%的人有孩子。44%的人没有约会经历，52%的人从未有过性行为。抑郁很常见，尤其是在性腺功能减退的患者中。幼稚化是最常见的主诉。我们未发现患者与其兄弟姐妹在最高教育成就和就业水平上存在差异，但发现结婚的兄弟姐妹明显更多。生长激素缺乏症患者存在抑郁、社会隔离和依赖的生活方式。作为治疗的一部分，应为患者及其家人提供适当的医学和心理咨询。
