采用聚合酶链反应-序列特异性寡核苷酸（PCR-SSO）进行常规HLA-B基因分型检测出八个新等位基因：B*0807、B*0809、B*1551、B*3529、B*3532、B*4025、B*5304和B*5508。
Routine HLA-B genotyping with PCR-sequence-specific oligonucleotides (PCR-SSO) detects eight new alleles: B*0807, B*0809, B*1551, B*3529, B*3532, B*4025, B*5304 and B*5508.
作者信息
Kennedy C T, Dodd R, Le T, Wallace R, Ng G, Greville W D, Kennedy A, Taverniti A, Moses J H, Clow N, Watson N, Dunckley H
机构信息
Molecular Genetics Laboratory, Tissue Typing, Australian Red Cross Blood Service, Sydney, New South Wales, Australia.
出版信息
Tissue Antigens. 2000 Mar;55(3):266-70. doi: 10.1034/j.1399-0039.2000.550311.x.
This paper describes eight new alleles (B0807, B0809, B1551, B3529, B3532, B4025, B5304 and B5508) that have been found by routine HLA-B genotyping with sequence-specific oligonucleotides (SSOs). All of the new alleles have variations which cause changes in residues that occur within antigen binding pockets and T-cell recognition sites of the antigen. The new polymorphisms within these new alleles may affect the nature and specificity of peptide binding and cause differential T-cell activation, which may have an affect in transplantation.
本文描述了通过序列特异性寡核苷酸（SSO）进行常规HLA - B基因分型发现的八个新等位基因（B0807、B0809、B1551、B3529、B3532、B4025、B5304和B5508）。所有新等位基因都存在变异，这些变异导致抗原结合口袋和抗原的T细胞识别位点内的残基发生变化。这些新等位基因内的新多态性可能会影响肽结合的性质和特异性，并导致不同的T细胞活化，这可能对移植产生影响。
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