HLA - B*1559：一种杂合等位基因，包含HLA - B35的第2外显子和HLA - B15的第3外显子，血清学分型为B35。
HLA-B*1559: a hybrid allele including exon 2 of HLA-B35 and exon 3 of HLA-B15 and serologically typed as B35.
作者信息
Magira E, Beznik-Cizman B, Monos D
机构信息
Department of Pediatrics, University of Pennsylvania School of Medicine and the Children's Hospital of Philadelphia, USA.
出版信息
Tissue Antigens. 2000 Nov;56(5):460-2. doi: 10.1034/j.1399-0039.2000.560512.x.
The new allele HLA-B1559 described is of Hispanic origin. This allele carries the exon 2 of HLA-B35 alleles, and is identical to HLA-B3501 and the exon 3 of HLA-B1530. Serologically it is typed as B35. The most likely scenario for its generation seems to be a gene conversion event that involved the, frequent in Hispanic populations, B1522 allele and a B1530 allele. A segment of the B1530 allele that included at least the sequences 412-419 would be transferred on a B1522 background.
所描述的新等位基因HLA - B1559起源于西班牙裔。该等位基因携带HLA - B35等位基因的第2外显子，与HLA - B3501以及HLA - B1530的第3外显子相同。血清学上它被分型为B35。其产生的最可能情况似乎是一次基因转换事件，涉及在西班牙裔人群中常见的B1522等位基因和一个B1530等位基因。包含至少序列412 - 419的B1530等位基因片段会转移到B1522背景上。
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