Johansen J K, Lose G
Gynaekologisk/obstetrisk afdeling, Amtssygehuset i Glostrup.
Ugeskr Laeger. 1999 Nov 1;161(44):6052-5.
Conventional oral pharmacotherapy for urge incontinence remains problematic because of limited efficacy and systemic side effects. In this study 27 patients with severe urge incontinence were treated with intravesical drugs (emepron 200 mg or oxybutynin 5 mg) twice a day. They had previously on average undergone 3.3 other treatment options without satisfactory effect. The average age was 62 years, and their incontinence had on average lasted for 15 years. Seven percent were cured and 41% were improved. Fifty-two percent had no satisfactory effect of the treatment. The number of side effects was low, and none left the study for this reason. Intravesical anticholinergic pharmacotherapy can be a treatment option in women with severe urge incontinence.
由于疗效有限和全身副作用，传统的口服药物治疗急迫性尿失禁仍然存在问题。在本研究中，27例严重急迫性尿失禁患者接受膀胱内药物治疗（依美普明200毫克或奥昔布宁5毫克），每天两次。他们此前平均已经尝试过3.3种其他治疗方法，但效果不佳。平均年龄为62岁，尿失禁平均持续了15年。7%的患者治愈，41%的患者病情改善。52%的患者治疗效果不理想。副作用数量较少，没有患者因此退出研究。膀胱内抗胆碱能药物治疗可以作为重度急迫性尿失禁女性的一种治疗选择。
