Trübenbach J, Pereira P L, Graepler F, Huppert P E, Eul T, König C W, Duda S H, Claussen C D
Abteilung für Radiologische Diagnostik, Eberhard-Karls-Universität Tübingen.
Rofo. 2000 Mar;172(3):274-7. doi: 10.1055/s-2000-112.
To evaluate the effect of permanent occlusion of the hepatic artery on the efficacy of transarterial chemoembolization (TACE) in an animal model.
12 days after inoculation of the Morris hepatoma 3924 A in 15 male ACI rats, TACE with Mitomycin C (0.25 mg/kgBW) + Lipiodol (0.2 ml/kgBW) without (n = 5) and with permanent occlusion of the hepatic artery (n = 5) was performed. Control group consisted of 5 rats. Tumor volume was determined by MRI (1.0 T, T1 [TR/TE, 400/14 ms]) before and 12 days after therapy.
Compared to the control group, TACE without and with permanent occlusion of the hepatic artery showed a significant reduced tumor growth after 12 days (p = 0.017 and p = 0.005). However, permanent occlusion did not improve the retarding effect on tumor growth (p = 0.9).
The effectiveness of TACE in an animal model using a cytostatic-/lipiodol-emulsion is not improved by permanent occlusion of the hepatic artery.
在动物模型中评估肝动脉永久性闭塞对经动脉化疗栓塞术（TACE）疗效的影响。
给15只雄性ACI大鼠接种Morris肝癌3924 A，12天后，对其中5只大鼠进行丝裂霉素C（0.25 mg/kg体重）+碘油（0.2 ml/kg体重）的TACE且不进行肝动脉永久性闭塞，对另外5只大鼠进行丝裂霉素C（0.25 mg/kg体重）+碘油（0.2 ml/kg体重）的TACE并进行肝动脉永久性闭塞。对照组由5只大鼠组成。在治疗前及治疗后12天通过磁共振成像（1.0 T，T1加权像[重复时间/回波时间，400/14 ms]）测定肿瘤体积。
与对照组相比，未进行肝动脉永久性闭塞及进行了肝动脉永久性闭塞的TACE组在12天后肿瘤生长均显著减缓（p = 0.017和p = 0.005）。然而，肝动脉永久性闭塞并未增强对肿瘤生长的抑制作用（p = 0.9）。
在使用细胞毒性药物/碘油乳剂的动物模型中，肝动脉永久性闭塞并不能提高TACE的疗效。
