Lü Liang-shan, Ma Qing-yong, Liu Ya-min
Department of Gastroenterology, First Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an 710061, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2009 Oct;29(10):2084-7.
To evaluate the effect of transcatheter arterial chemoembolization (TACE) with high-dose iodized oil on hepatic tumor growth and metastasis in rabbits.
Forty-eight rabbits with implanted VX2 tumor were randomly divided into control group, routine dose iodized oil TACE group and high-dose iodized oil TACE group to receive perfusion through the hepatic artery with 0.9% saline, 5 mg adriamycin with routine-dose iodized oil, and 5 mg adriamycin with high-dose iodized oil, respectively. The tumor volume, tumor necrosis, intrahepatic and lung metastasis were examined 2 weeks after TACE.
No significant difference was found in the tumor volume between the 3 groups before TACE (P>0.05). The rabbits receiving TACE with iodized oil, especially at the high dose, showed significantly reduced tumor volume as compared with the control group (P<0.01). TACE with high-dose iodized oil resulted in significantly increased tumor necrosis rate in comparison with the control group and TACE with a routine dose of iodized oil (P<0.05); high-dose iodized oil TACE was also associated with reduced intrahepatic and lung metastasis as compared routine dose iodized oil TACE (P<0.05).
TACE with high-dose iodized oil can obviously inhibit the growth and intrahepatic and lung metastasis of transplanted VX2 liver tumor in rabbits .
评估高剂量碘化油经动脉化疗栓塞术（TACE）对兔肝肿瘤生长和转移的影响。
48只植入VX2肿瘤的兔被随机分为对照组、常规剂量碘化油TACE组和高剂量碘化油TACE组，分别经肝动脉灌注0.9%生理盐水、5mg阿霉素与常规剂量碘化油、5mg阿霉素与高剂量碘化油。TACE术后2周检查肿瘤体积、肿瘤坏死情况、肝内及肺转移情况。
TACE术前3组肿瘤体积差异无统计学意义（P>0.05）。接受碘化油TACE治疗的兔，尤其是高剂量组，与对照组相比肿瘤体积显著减小（P<0.01）。与对照组和常规剂量碘化油TACE相比，高剂量碘化油TACE导致肿瘤坏死率显著增加（P<0.05）；与常规剂量碘化油TACE相比，高剂量碘化油TACE还可减少肝内及肺转移（P<0.05）。
高剂量碘化油TACE可明显抑制兔移植VX2肝肿瘤的生长及肝内和肺转移。
