Mizutani F, Sugiyama K, Goto K, Ando T, Terabe K, Wada Y
Department of Pediatrics, Nagoya City University Medical School, Japan.
Tohoku J Exp Med. 2000 Mar;190(3):185-92. doi: 10.1620/tjem.190.185.
The prevalence of serum GB virus C (GBV-C)/Hepatitis G virus (HGV) RNA and anti-E2 was investigated in Japanese children younger than 16 years of age without a history of blood transfusion and the family members of serum GBV-C/HGV RNA-positive children. The prevalences of serum GBV-C/HGV RNA and anti-E2 were 0.5% (5/1000) and 0% (0/330), respectively. Viral RNA was also detected in the mothers of all five GBV-C/HGV RNA-positive children and in two of their siblings. Sequence determinations indicated the likelihood of mother-to-infant transmission in all cases. The presence of the virus persisted for at least 10-18 months in all 5 children, without any appearance of anti-E2.
对无输血史的16岁以下日本儿童及其血清GB病毒C（GBV-C）/庚型肝炎病毒（HGV）RNA阳性儿童的家庭成员进行了血清GBV-C/HGV RNA和抗-E2的流行情况调查。血清GBV-C/HGV RNA和抗-E2的流行率分别为0.5%（5/1000）和0%（0/330）。在所有5名GBV-C/HGV RNA阳性儿童的母亲及其两名兄弟姐妹中也检测到了病毒RNA。序列测定表明所有病例均存在母婴传播的可能性。所有5名儿童体内病毒持续存在至少10 - 18个月，且均未出现抗-E2。
