Watanabe S, Hirose M, Wang X E, Kobayashi O, Nagahara A, Murai T, Iwazaki R, Miwa H, Miyazaki A, Sato N
First Department of Internal Medicine, Akita University School of Medicine, Japan.
J Gastroenterol. 2000;35 Suppl 12:65-8.
In this review article we discuss the role of growth factors in gastric ulcer healing using an in vitro wound repair model with gastric epithelial and mesenchymal cells. Several growth factors accelerate gastric epithelial and mesenchymal wound healing in vitro with acceleration of cell migration and proliferation. Epidermal growth factor, transforming growth factor-alpha (TGFalpha), hepatocyte growth factor, and insulin accelerate predominantly gastric epithelial wound healing; and TGFbeta and basic fibroblast growth factor predominantly accelerate gastric mesenchymal wound healing. Platelet-derived growth factor-betabeta and insulin-like growth factor-1 (IGF-1) accelerate both significantly. Among these growth factors, IGF-1 produced from fibroblasts plays a key role in the gastric epithelial-mesenchymal interaction during the process of gastric wound healing.
在这篇综述文章中，我们使用胃上皮细胞和间充质细胞的体外伤口修复模型，讨论了生长因子在胃溃疡愈合中的作用。几种生长因子可加速胃上皮和间充质细胞的体外伤口愈合，促进细胞迁移和增殖。表皮生长因子、转化生长因子-α（TGFα）、肝细胞生长因子和胰岛素主要加速胃上皮伤口愈合；而TGFβ和碱性成纤维细胞生长因子主要加速胃间充质伤口愈合。血小板衍生生长因子-β和胰岛素样生长因子-1（IGF-1）两者均能显著加速愈合。在这些生长因子中，成纤维细胞产生的IGF-1在胃伤口愈合过程中的胃上皮-间充质相互作用中起关键作用。
