Saw S M, Tan N, Lee S B, Au Eong K G, Chia K S
Department of Community, Occupational, and Family Medicine, National University of Singapore, Republic of Singapore.
J Pediatr Ophthalmol Strabismus. 2000 Mar-Apr;37(2):87-93. doi: 10.3928/0191-3913-20000301-07.
To describe the incidence and survival of 69 Singapore residents with retinoblastoma in all Singapore hospitals from 1968-1995.
Data of all Singapore residents diagnosed with retinoblastoma from 1968-1995 were collected by the Singapore Cancer Registry based on notifications from physicians, pathology records, hospital discharge records, and death certificates. The medical records of 46 patients were traced, and information on laterality of tumor, spread of tumor, mode of treatment, and family history of retinoblastoma was obtained. Time trends and survival characteristics of the cohort were described.
The incidence rate of retinoblastoma was 2.4 per 1 million for children <9 years and 11.1 per 1 million for children <5 years. The incidence of retinoblastoma has been almost uniform over time from 1968-1995, except for an apparent increase in 1988-1992. The 3-year survival rate for retinoblastoma was 83%. Survival rates were higher in children <2 years because children who present at a younger age may have tumors diagnosed at earlier stages of the disease. There was no difference in survival rates for sex, race, laterality, family history of retinoblastoma, treatment, or year of diagnosis.
Retinoblastoma is the most common eye cancer in children that may cause blindness or death. The incidence rates of retinoblastoma in Singapore have remained fairly stable over 28 years, and the survival rate is higher in younger children. This study will be helpful in monitoring future disease patterns in Asian populations.
描述1968年至1995年间新加坡所有医院收治的69例视网膜母细胞瘤新加坡居民的发病率和生存率。
新加坡癌症登记处根据医生通知、病理记录、医院出院记录和死亡证明，收集了1968年至1995年期间所有被诊断为视网膜母细胞瘤的新加坡居民的数据。追踪了46例患者的病历，获取了肿瘤的患侧性、肿瘤扩散情况、治疗方式以及视网膜母细胞瘤家族史等信息。描述了该队列的时间趋势和生存特征。
9岁以下儿童视网膜母细胞瘤的发病率为每100万人中2.4例，5岁以下儿童为每100万人中11.1例。1968年至1995年期间，视网膜母细胞瘤的发病率基本保持一致，1988年至1992年期间有明显上升除外。视网膜母细胞瘤的3年生存率为83%。2岁以下儿童的生存率更高，因为年龄较小的儿童可能在疾病的早期阶段被诊断出患有肿瘤。在性别、种族、患侧性、视网膜母细胞瘤家族史、治疗方式或诊断年份方面，生存率没有差异。
视网膜母细胞瘤是儿童中最常见的眼癌，可能导致失明或死亡。新加坡视网膜母细胞瘤的发病率在28年里一直保持相当稳定，年龄较小的儿童生存率更高。这项研究将有助于监测亚洲人群未来的疾病模式。
