Department of Ophthalmology, National University Hospital, Singapore.
Ann Acad Med Singap. 2021 Apr;50(4):297-305. doi: 10.47102/annals-acadmedsg.2020488.
Limited data are available on the incidence of primary ophthalmic cancers worldwide. We describe the incidence and trends of primary ophthalmic cancers in Singapore.
Data on ophthalmic cancers diagnosed in Singapore from 1996 to 2016 were retrieved from the Singapore Cancer Registry for analysis. All were histologically proven primary ophthalmic cancers. Calculations of incidence and age-specific frequency of ophthalmic malignancy were made.
A total of 297 cases were included, with males constituting 59.9%. The race distribution was 78.5% Chinese, 16.5% Malay, 3.7% Indians and 1.3% others. There was an overall increase in ophthalmic malignancies. The mean age of onset was 47.4 years. The most common cancers were retinoblastoma (93.3%) in patients younger than 15 years, and lymphoma (71.3%) in patients aged 15 years and older. There has been an increase in lymphomas from 16.7% in 1968-1995 to 71.3% in 1996-2016 in those aged 15 years and older. The most common types of ophthalmic cancer according to location are lymphoma of the orbit, conjunctiva, cornea and lacrimal gland; retinoblastoma of the retina; and malignant melanoma of the choroid and ciliary body.
Our study reported the incidence and trends of ophthalmic cancer in the Singapore population and showed an overall increase in ophthalmic malignancies in Singapore from 1996-2016. A substantial increase in lymphomas over the last 2 decades was noted. The data could aid clinicians, epidemiologists and policymakers in implementing strategies to address trends in ophthalmic cancers and spur aetiological research to improve quality of life in patients with such cancers.
全球范围内原发性眼癌的发病率数据有限。我们描述了新加坡原发性眼癌的发病率和趋势。
从新加坡癌症登记处检索了 1996 年至 2016 年期间在新加坡诊断出的眼癌数据进行分析。所有病例均经组织学证实为原发性眼癌。计算了眼癌发病率和年龄别眼癌发病率。
共纳入 297 例，男性占 59.9%。种族分布为 78.5%华人、16.5%马来人、3.7%印度人和 1.3%其他种族。眼癌总体呈上升趋势。发病的平均年龄为 47.4 岁。最常见的癌症是 15 岁以下患者的视网膜母细胞瘤（93.3%），以及 15 岁及以上患者的淋巴瘤（71.3%）。15 岁及以上人群的淋巴瘤从 1968-1995 年的 16.7%增加到 1996-2016 年的 71.3%。根据部位分类，最常见的眼癌类型为眼眶、结膜、角膜和泪腺的淋巴瘤；视网膜的视网膜母细胞瘤；脉络膜和睫状体的恶性黑色素瘤。
本研究报告了新加坡人群的眼癌发病率和趋势，并显示了新加坡 1996-2016 年眼癌的总体发病率呈上升趋势。过去 20 年，淋巴瘤的发病率显著增加。这些数据可以帮助临床医生、流行病学家和决策者实施策略，应对眼癌的趋势，并促进病因学研究，以提高此类癌症患者的生活质量。
