Hermann K, Ring J
Department of Dermatology, University Clinic Eppendorf, University of Hamburg, Germany.
Clin Exp Allergy. 1993 Sep;23(9):762-9. doi: 10.1111/j.1365-2222.1993.tb00364.x.
Components of the renin angiotensin system, namely renin, angiotensinogen, angiotensin I and II and aldosterone were measured in plasma of patients with hymenoptera venom anaphylaxis (n = 50) and healthy non-allergic controls (n = 25). Patients with a history of anaphylactic reactions to hymenoptera venom who did not undergo immunotherapy showed significantly reduced renin, angiotensinogen, angiotensin I and angiotensin II in plasma as compared with controls (P < 0.05). There was no difference in the aldosterone concentration between patients and controls. Angiotensin I, angiotensin II, renin and angiotensinogen levels were the same in male and female patients. There was also no difference in the angiotensin I, II, renin or angiotensinogen levels between young and older patients. A significant inverse correlation between the severity of clinical symptoms and the plasma levels of renin (r = -0.382, P < 0.001), angiotensinogen (r = -0.567, P < 0.0001), angiotensin I (r = -0.656, P < 0.0001) and angiotensin II (r = 0.0762, P < 0.0001) was found: the lower the levels the more severe the clinical symptoms. No correlation was found for aldosterone. Hymenoptera venom allergic patients with repeated anaphylactic reactions during hyposensitization did not tolerate the sting of a living insect (n = 6). In these patients, renin, angiotensinogen, angiotensin I and II remained significantly lower than in healthy non-allergic controls. Patients with successful immunotherapy (n = 27) who tolerated the sting of a living insect had renin, angiotensin I and II significantly higher than patients without immunotherapy. These findings suggest a possible role of the renin angiotensin system in hymenoptera venom anaphylaxis.
在膜翅目毒液过敏患者（n = 50）和健康非过敏对照者（n = 25）的血浆中，检测了肾素 - 血管紧张素系统的组成成分，即肾素、血管紧张素原、血管紧张素I和II以及醛固酮。有膜翅目毒液过敏反应病史但未接受免疫治疗的患者，其血浆中的肾素、血管紧张素原、血管紧张素I和血管紧张素II与对照组相比显著降低（P < 0.05）。患者与对照组之间的醛固酮浓度无差异。男性和女性患者的血管紧张素I、血管紧张素II、肾素和血管紧张素原水平相同。年轻患者和老年患者之间的血管紧张素I、II、肾素或血管紧张素原水平也无差异。临床症状的严重程度与血浆肾素水平（r = -0.382，P < 0.001）、血管紧张素原水平（r = -0.567，P < 0.0001）、血管紧张素I水平（r = -0.656，P < 0.0001）和血管紧张素II水平（r = 0.0762，P < 0.0001）之间存在显著负相关：水平越低，临床症状越严重。未发现醛固酮有相关性。在减敏治疗期间有反复过敏反应的膜翅目毒液过敏患者不能耐受活昆虫叮咬（n = 6）。在这些患者中，肾素、血管紧张素原、血管紧张素I和II仍显著低于健康非过敏对照者。成功接受免疫治疗且能耐受活昆虫叮咬的患者（n = 27），其肾素、血管紧张素I和II显著高于未接受免疫治疗的患者。这些发现提示肾素 - 血管紧张素系统在膜翅目毒液过敏反应中可能发挥作用。
