Hermann K, von Tschirschnitz M, Ebner von Eschenbach C, Ring J
Department of Dermatology, University Hospital Eppendorf, University of Hamburg, Germany.
Int Arch Allergy Immunol. 1994 Aug;104(4):379-84. doi: 10.1159/000236695.
Markers of immediate-type hypersensitivity such as histamine and tryptase were measured in the plasma of nonallergic volunteers and patients with a history of hymenoptera venom anaphylaxis. No significant differences in histamine or tryptase were found between patients and controls. Norepinephrine, an important compound involved in the control of cardiovascular functions and blood pressure, was the same in patients and nonallergic volunteers. In addition, components of the renin-angiotensin system were determined. Patients with hymenoptera venom anaphylaxis showed significantly lower plasma angiotensinogen concentrations as compared to healthy nonallergic controls (p < 0.007), whereas plasma ACE activity was the same. Likewise, the plasma levels of angiotensin I and angiotensin II were significantly reduced in patients as compared to controls (p < 0.04 and p < 0.003, respectively). These findings suggest that the renin-angiotensin system may play an important role as a counteracting factor in hymenoptera venom anaphylaxis.
在非过敏性志愿者和有膜翅目毒液过敏史的患者血浆中，检测了组胺和类胰蛋白酶等速发型超敏反应标志物。患者与对照组之间在组胺或类胰蛋白酶方面未发现显著差异。去甲肾上腺素是参与心血管功能和血压控制的重要化合物，在患者和非过敏性志愿者中水平相同。此外，还测定了肾素 - 血管紧张素系统的成分。与健康的非过敏性对照组相比，膜翅目毒液过敏患者的血浆血管紧张素原浓度显著降低（p < 0.007），而血浆ACE活性相同。同样，与对照组相比，患者的血浆血管紧张素I和血管紧张素II水平也显著降低（分别为p < 0.04和p < 0.003）。这些发现表明，肾素 - 血管紧张素系统可能作为膜翅目毒液过敏的一种对抗因素发挥重要作用。
