Picart N, Périole B, Mazereeuw J, Bonafé J L
Service de Dermatologie, CHU Rangueil, Toulouse.
Presse Med. 2000 Apr 1;29(12):648-50.
Drug-induced hypersensitivity syndrome is an uncommon but potentially life-threatening idiosyncratic drug reaction. It is usually due to aromatic anti-convulsants. We report the second case induced by sodium valproate, a non-aromatic anticonvulsant.
A 28-year-old woman was treated with sodium valproate for 5 weeks. She suddenly developed a generalized maculo-papulous eruption with fever, node enlargement, hypereosinophilia and altered liver function.
Drug-induced hypersensitivity is rarely induced by valproic acid. The time-course and positive patch tests using the diluted drug establish the diagnosis.
药物性超敏反应综合征是一种罕见但可能危及生命的特异质性药物反应。它通常由芳香族抗惊厥药引起。我们报告了第二例由非芳香族抗惊厥药丙戊酸钠诱发的病例。
一名28岁女性接受丙戊酸钠治疗5周。她突然出现全身性斑丘疹，伴有发热、淋巴结肿大、嗜酸性粒细胞增多和肝功能改变。
丙戊酸很少诱发药物性超敏反应。使用稀释药物的时间进程和阳性斑贴试验确立了诊断。
