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Fatal sodium valproate-induced hypersensitivity syndrome with lichenoid dermatitis and fulminant hepatitis.

作者信息

Huang Yau-Li, Hong Hong-Shang, Wang Zen-Whe, Kuo Tseng-tong

机构信息

Department of Dermatology Chang Gung Memorial Hospital, Taipei, Taiwan.

出版信息

J Am Acad Dermatol. 2003 Aug;49(2):316-9. doi: 10.1067/s0190-9622(03)00748-5.

DOI:10.1067/s0190-9622(03)00748-5
PMID:12894087
Abstract

Anticonvulsant hypersensitivity syndrome caused by sodium valproate (Depakene) has rarely been reported. Here we describe a patient who presented with nonspecific polymorphous eruptions, fulminant hepatitis, and jaundice. Lichenoid dermatitis was found in the skin biopsy specimen. Toxic hepatitis and microvesicular steatosis were found in the liver biopsy specimen, consistent with valproate hepatotoxicity.

摘要

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