Variable pattern of visual recovery of Leber's hereditary optic neuropathy.
作者信息
Nakamura M, Yamamoto M
机构信息
Department of Ophthalmology, Kobe University School of Medicine, Kobe, Japan.
出版信息
Br J Ophthalmol. 2000 May;84(5):534-5. doi: 10.1136/bjo.84.5.534.
Abstract
AIMS
To investigate pattern of visual recovery of nine patients with Leber's hereditary optic neuropathy (LHON) and a mitochondrial DNA mutation at 11778.
METHODS
Recovery was judged significant when a gain of two lines or more in the Landolt ring chart, 10 dB or more improvement of the mean deviation of static perimetry, or improvement of critical flicker frequency (CFF) over 35 Hz was shown.
RESULTS
All three visual functions tested dramatically recovered in one patient. Two other patients exhibited isolated improvement of CFF or visual field, respectively.
CONCLUSION
Partial improvement of visual function may be more widespread than previously recognised in LHON patients with the 11778 mutation.
摘要
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本文引用的文献
1
Clinical, biochemical and molecular genetic features of Leber's hereditary optic neuropathy.
Biochim Biophys Acta. 1999 Feb 9;1410(2):147-58. doi: 10.1016/s0005-2728(98)00163-7.
2
[Basic and clinical aspects of modern perimetry].
Nippon Ganka Gakkai Zasshi. 1998 Dec;102(12):779-95.
3
Clinical spectrum of Leber's hereditary optic neuropathy.
Clin Neurosci. 1997;4(5):295-301.
4
Ophthalmologic findings in Leber hereditary optic neuropathy, with special reference to mtDNA mutations.
Ophthalmology. 1996 Mar;103(3):504-14. doi: 10.1016/s0161-6420(96)30665-9.
5
Homoplasmic and exclusive ND4 gene mutation in Japanese pedigrees with Leber's disease.
Invest Ophthalmol Vis Sci. 1993 Mar;34(3):488-95.
6
Critical flicker frequency in acute and recovered optic neuritis.
Jpn J Ophthalmol. 1993;37(2):122-9.
7
Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy.
Science. 1988 Dec 9;242(4884):1427-30. doi: 10.1126/science.3201231.
8
Impaired critical flicker frequency in recovered optic neuritis.
Ann Neurol. 1991 Aug;30(2):213-5. doi: 10.1002/ana.410300216.
9
Visual recovery in patients with Leber's hereditary optic neuropathy and the 11778 mutation.
J Clin Neuroophthalmol. 1992 Mar;12(1):10-4.
10
Remission of Leber's hereditary optic neuropathy with idebenone.
Lancet. 1992 Aug 8;340(8815):368-9. doi: 10.1016/0140-6736(92)91442-b.
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