Woung L C, Wakakura M, Ishikawa S
Department of Ophthalmology, Kitasato University, School of Medicine, Kanagawa, Japan.
Jpn J Ophthalmol. 1993;37(2):122-9.
Multiple occasional changes in critical flicker frequency (CFF) were studied in patients who recovered from optic neuritis. Twenty-five patients (31 affected eyes) with onset visual acuity less than 0.5 and who showed recovered visual acuity exceeding 1.0 were included in this study. Recovery stages were determined individually as follows: T1, initial onset stage; T2, intermediate stage; T3, recovered stage when visual acuity was 1.0 or better; and T4, final follow-up stage. CFF was determined using red, yellow and green illuminated targets in a compact CFF measuring device recently developed at our department. The rates of abnormality were 100% at stage T1 for all colors, and gradually decreased as the stage advanced from T2 to T4. However, the rates of abnormality continued to be high at 67% in stage T3 for the red target and 37% in stage T4 for the red target. The rates of abnormal interocular difference in CFF in 15 unilateral optic neuritis patients were 100% for all colors at stage T1 and decreased gradually with recovery. Slight but definite abnormality of CFF was also noted in the silent eyes of clinically unilateral optic neuritis patients. The rates of abnormal CFF more than 7% in all colors could be detected in T1, T3 and T4. These results indicate that CFF abnormality can be detected even at the stage of recovery in the pathologic eyes and the fellow eyes of optic neuritis patients. CFF was also shown to be a sensitive indicator for detecting visual dysfunction in patients with optic neuritis.
对从视神经炎中恢复的患者的临界闪烁频率（CFF）的多次偶然变化进行了研究。本研究纳入了25例患者（31只患眼），这些患者起病时视力低于0.5，恢复后视力超过1.0。恢复阶段分别确定如下：T1，初始发病阶段；T2，中间阶段；T3，视力为1.0或更好的恢复阶段；T4，最终随访阶段。使用我们科室最近研制的紧凑型CFF测量装置，通过红色、黄色和绿色照明靶标测定CFF。所有颜色在T1阶段的异常率均为100%，随着阶段从T2进展到T4，异常率逐渐降低。然而，红色靶标在T3阶段的异常率仍高达67%，在T4阶段为37%。15名单侧视神经炎患者CFF的眼间差异异常率在T1阶段所有颜色均为100%，并随着恢复逐渐降低。在临床单侧视神经炎患者的健眼中也注意到CFF有轻微但明确的异常。在T1、T3和T4阶段，可以检测到所有颜色的CFF异常率超过7%。这些结果表明，在视神经炎患者的患眼和健眼中，即使在恢复阶段也能检测到CFF异常。CFF也被证明是检测视神经炎患者视觉功能障碍的敏感指标。
