Juanola X, Mateo L, Nolla J M, Roig-Vilaseca D, Campoy E, Roig-Escofet D
Rheumatology Service, Ciutat Sanitària i Universitària de Bellvitge, Hospital Princeps d'Espanya, L'Hospitalet de Llobregat, Barcelona, Spain.
J Rheumatol. 2000 Apr;27(4):1028-31.
To determine bone mineral density (BMD) in premenopausal women with early ankylosing spondylitis (AS).
Eighteen premenopausal women with AS without syndesmophytes, interapophysiary arthritis, and/or coxofemoral joint destruction were studied. BMD was analyzed at lumbar spine and femoral neck by dual energy x-ray absorptiometry (Hologic QDR 1000). Z scores and T scores related to the general Spanish population were recorded. Comparisons were performed using the Student t test. Pearson's correlation coefficients were used to study the correlation between BMD and the variables. Following the WHO classification, osteopenia was diagnosed in patients with T score between -1 and -2.5 and osteoporosis in those with T score < -2.5 at lumbar spine or femoral neck.
The mean Z score for spine BMD was -0.19+/-0.7, and -0.03+/-0.85 for femoral neck BMD. There were no significant differences of Z score values compared to the general population. No significant correlation was found between BMD and disease duration, radiology sacroiliac score, and spine mobility. Densitometry showed osteopenia in 2 patients and osteoporosis in none.
We found a slight reduction in BMD in premenopausal women with early AS, but the difference was not statistically significant. We discuss the factors related to its pathogenesis.
测定绝经前早期强直性脊柱炎（AS）女性的骨密度（BMD）。
对18例无韧带骨赘、椎间关节炎和/或髋股关节破坏的绝经前AS女性进行研究。采用双能X线吸收法（Hologic QDR 1000）分析腰椎和股骨颈的骨密度。记录与西班牙普通人群相关的Z值和T值。采用Student t检验进行比较。使用Pearson相关系数研究骨密度与各变量之间的相关性。根据世界卫生组织的分类标准，腰椎或股骨颈T值在-1至-2.5之间的患者诊断为骨质减少，T值＜-2.5的患者诊断为骨质疏松。
脊柱骨密度的平均Z值为-0.19±0.7，股骨颈骨密度的平均Z值为-0.03±0.85。与普通人群相比，Z值无显著差异。骨密度与病程、放射学骶髂关节评分和脊柱活动度之间未发现显著相关性。骨密度测定显示2例患者有骨质减少，无患者有骨质疏松。
我们发现绝经前早期AS女性的骨密度略有降低，但差异无统计学意义。我们讨论了与其发病机制相关的因素。
