Morita A, Asakura H, Morishita T, Hibi T, Shimabukuro K, Tsuchiya M
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
Angiology. 1976 Nov;27(11):622-33. doi: 10.1177/000331977602701103.
Bipedal lymphography was performed in 5 cases of Behçet's disease. In 4 of 5 cases, histologic examination of intestinal biopsy specimens showed lymphatic dilatation of the small intestine which were considered to be a characteristic finding of intestinal lymphangiectasia, a protein-losing enteropathy, but no patient with Behçet's disease showed reduced concentration of serum total protein as well as abnormal value of 131I-PVP test. Lymphograms showed an increase in number of iliopelvic and lumbar lymphatic vessels as a major finding, but they failed to demonstrate a hypoplasia or aplasia of lymphatic system or obstruction of thoracic duct. It is conceivable that the lymphatic dilatation of the small intestine in Behçet's disease may be related to increased flow of lymph due to excessive vascular hyperpermeability and may not be related to a block of lymphatic system which has been considered to be a cause of enteric protein loss in intestinal lymphangiectasia. The authors wish to emphasize that the dilatation of lymphatic vessel of the small intestine is not a sufficient finding to indicate the presence of protein-losing enteropathy.
对5例白塞病患者进行了双足淋巴管造影。5例中的4例，小肠活检标本的组织学检查显示小肠淋巴管扩张，这被认为是肠淋巴管扩张症（一种蛋白丢失性肠病）的特征性表现，但没有白塞病患者出现血清总蛋白浓度降低以及131I-聚乙烯吡咯烷酮试验异常值。淋巴管造影显示主要表现为髂盆腔和腰淋巴管数量增加，但未显示淋巴系统发育不全或发育不良或胸导管阻塞。可以想象，白塞病中小肠淋巴管扩张可能与血管通透性过高导致的淋巴流量增加有关，而可能与被认为是肠淋巴管扩张症中肠道蛋白丢失原因的淋巴系统阻塞无关。作者希望强调，小肠淋巴管扩张不足以表明存在蛋白丢失性肠病。
