Aguado P, Garcés M V, González Casaús M L, del Campo M T, Richi P, Coya J, Torrijos A, Gijón J, Martín Mola E, Martínez M E
Servicio de Reumatología, Hospital Universitario La Paz, Madrid.
Med Clin (Barc). 2000 Mar 11;114(9):326-30. doi: 10.1016/s0025-7753(00)71283-8.
Vitamin D deficiency has been frequently observed in the elderly population in Europe. However few information is available about the vitamin D status in postmenopausal women in the Mediterranean countries. The aim of this study was to evaluate the vitamin D status assessed by serum 25(OH)D3 (calcidiol) in postmenopausal women who attended a Rheumatology practice in Madrid area, and to evaluate calcidiol serum levels through one year after two forms of vitamin D administration.
Calcidiol serum levels were measured in 171 postmenopausal women (111 with osteoporosis and 60 without osteoporosis). 82 women with calcidiol serum levels < 10 ng/ml were distributed in two groups: Group I received 800 U/day of vitamin D3 associated with calcium (1 g/day) and group II, one dose of 80,000 U vitamin D orally as calcidiol and latter a daily dose of 800 U vitamin D3 plus 1 g calcium. Calcidiol serum levels were measured by RIA in both groups at basal condition and after three, six and twelve months under treatment.
Three cut-offs were considered: 10, 15 and 20 ng/ml of calcidiol. Percentages of postmenopausal women with vitamin D deficiency for such cut-offs were: 35.3%, 64.1% and 87.1%, respectively. After three months of treatment, women from group II showed calcidiol serum levels higher than group I. At six and twelve months calcidiol serum levels were similar in both groups.
A high prevalence of vitamin D deficiency was observed in a group of postmenopausal women who attended a rheumatology practice in Madrid area. Both forms of vitamin D administration seem not sufficient to maintain the adequate calcidiol serum levels in postmenopausal deficient women. A dose of 80,000 U of calcidiol twice a year should be considered.
维生素D缺乏在欧洲老年人群中屡见不鲜。然而，关于地中海国家绝经后女性的维生素D状况，相关信息却寥寥无几。本研究旨在评估马德里地区一家风湿病诊所就诊的绝经后女性血清25(OH)D3（骨化二醇）所评估的维生素D状况，并通过两种维生素D给药方式后一年来评估骨化二醇血清水平。
对171名绝经后女性（111名患有骨质疏松症，60名未患骨质疏松症）测定骨化二醇血清水平。82名骨化二醇血清水平<10 ng/ml的女性被分为两组：第一组每天接受800 U维生素D3加钙（1 g/天），第二组口服一剂80,000 U骨化二醇形式的维生素D，之后每天服用800 U维生素D3加1 g钙。两组在基础状态以及治疗后3个月、6个月和12个月时，均通过放射免疫分析测定骨化二醇血清水平。
设定了三个临界值：骨化二醇10、15和20 ng/ml。绝经后女性维生素D缺乏在这些临界值下的百分比分别为：35.3%、64.1%和87.1%。治疗3个月后，第二组女性的骨化二醇血清水平高于第一组。6个月和12个月时，两组的骨化二醇血清水平相似。
在马德里地区一家风湿病诊所就诊的绝经后女性群体中，观察到维生素D缺乏的高患病率。两种维生素D给药方式似乎都不足以维持绝经后缺乏维生素D女性的骨化二醇血清水平处于充足状态。应考虑每年两次给予80,000 U骨化二醇的剂量。
