单次高剂量或每日低剂量口服骨化三醇治疗对绝经后女性维生素D水平和肌肉力量的影响。
The effects of single high-dose or daily low-dosage oral colecalciferol treatment on vitamin D levels and muscle strength in postmenopausal women.
作者信息
Apaydin Mahmut, Can Asli Gencay, Kizilgul Muhammed, Beysel Selvihan, Kan Seyfullah, Caliskan Mustafa, Demirci Taner, Ozcelik Ozgur, Ozbek Mustafa, Cakal Erman
机构信息
Department of Endocrinology and Metabolism, Diskapi Training and Research Hospital, Ankara, Turkey.
Department of Physical Medicine and Rehabilitation, Diskapi Training and Research Hospital, Ankara, Turkey.
出版信息
BMC Endocr Disord. 2018 Jul 21;18(1):48. doi: 10.1186/s12902-018-0277-8.
INTRODUCTION
Vitamin D deficiency is a common health problem. Vitamin D supplements are used to improve vitamin D status; however, there are contradictory data related to what doses to give and how often they should be given. Many studies have investigated the effects of vitamin D supplementation on muscle strength, but the results remain controversial. We aimed to compare the effects and safety of single high-dose with daily low-dose oral colecalciferol on 25(OH)D levels and muscle strength in postmenopausal women with vitamin D deficiency or insufficiency.
METHODS AND DESIGN
Sixty healthy postmenopausal women who had serum vitamin D levels < 20 ng/mL (50 nmol/L) were enrolled in the study. Group 1 (n = 32) was given daily oral dosages of 800 IU vitamin D3, and group 2 (n = 28) was given a single oral dose of 300,000 IU vitamin D3. Serum vitamin D levels and muscle strengths were measured at the beginning, 4th, and 12th week. Muscle strength tests were performed at 60° using a Biodex system 3 isokinetic dynamometer.
RESULTS
Pretreatment vitamin D levels did not differ between the two groups (10.2 ± 4.4 ng/mL (25,4 ± 10,9 nmol/L); 9.7 ± 4.4 ng/mL (24,2 ± 10,9 nmol/L), p > 0.05). A significant increase in vitamin D levels was observed in both groups at 4 and 12 weeks after vitamin D3 treatment. The increase in the single-dose group was significantly higher than the daily low-dosage group at the 4th week (35.9 ± 9.6 ng/mL (89,6 ± 23,9 nmol/L), 16.9 ± 5.8 ng/mL (42,1 ± 14,4 nmol/L), p = 0.01). The increase in the single-dose group was significantly higher than in the daily low dosage group at the 12th week (23.4 ± 4.7 ng/mL (58,4 ± 11,7 nmol/L), 19.8 ± 7.2 ng/mL (49,4 ± 17,9 nmol/L), p = 0.049). The quadriceps muscle strength score increased significantly in the daily group at the 4th week (p = 0.038). The hamstring muscle strength score increased significantly in the daily group at the 12th week (p = 0.037).
CONCLUSION
Although daily administration routes are more effective in improving muscle strength, a single administration is more effective in increasing vitamin D levels.
TRIAL REGISTRATION NUMBER
ISRCTN14226530 (04.07.2018), Name of the registry: ISRCTN registry, The study was retrospectively registered.
引言
维生素D缺乏是一个常见的健康问题。维生素D补充剂用于改善维生素D状况；然而，关于给予何种剂量以及给药频率的数据存在矛盾。许多研究调查了补充维生素D对肌肉力量的影响，但结果仍存在争议。我们旨在比较单次高剂量与每日低剂量口服骨化三醇对维生素D缺乏或不足的绝经后女性25(OH)D水平和肌肉力量的影响及安全性。
方法与设计
60名血清维生素D水平<20 ng/mL（50 nmol/L）的健康绝经后女性纳入本研究。第1组（n = 32）每日口服800 IU维生素D3，第2组（n = 28）单次口服300,000 IU维生素D3。在研究开始时、第4周和第12周测量血清维生素D水平和肌肉力量。使用Biodex系统3等速测力计在60°进行肌肉力量测试。
结果
两组治疗前维生素D水平无差异（10.2±4.4 ng/mL（25.4±10.9 nmol/L）；9.7±4.4 ng/mL（24.2±10.9 nmol/L），p>0.05）。维生素D3治疗后第4周和第12周，两组维生素D水平均显著升高。第4周时，单次给药组的升高幅度显著高于每日低剂量组（35.9±9.6 ng/mL（89.6±23.9 nmol/L），16.9±5.8 ng/mL（42.1±14.4 nmol/L），p = 0.01）。第第12周时，单次给药组的升高幅度显著高于每日低剂量组（23.4±4.7 ng/mL（58.4±11.7 nmol/L），19.8±7.2 ng/mL（49.4±17.9 nmol/L），p = 0.049）。每日给药组在第4周时股四头肌力量评分显著增加（p = 0.038）。每日给药组在第12周时腘绳肌力量评分显著增加（p = 0.037）。
结论
虽然每日给药途径在改善肌肉力量方面更有效，但单次给药在提高维生素D水平方面更有效。
试验注册号
ISRCTN14226530（2018年7月4日），注册机构名称：ISRCTN注册机构，该研究为回顾性注册。
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