Fay M, Donohue J M, De Rosa C
Agency for Toxic Substances and Disease Registry, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333, USA.
Toxicol Ind Health. 1999 Dec;15(8):651-746. doi: 10.1177/074823379901500801.
Di(2-ethylhexyl)phthalate (also known as DEHP, bis(2-ethylhexyl)phthalate, or BEHP; CAS Registry Number 117-81-7) is a widely-used plasticizer. It is found in numerous plastic articles, such as paints, inks, floor tiles, upholstery, shower curtains, footwear, plastic bags, food-packaging materials, toys, and medical tubing. Not surprisingly, DEHP appears at many waste sites. As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals that are of greatest public health concern at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priority List (NPL) sites. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of the bulk of ATSDR's profile for DEHP (ATSDR, 1993) into the mainstream scientific literature. An extensive listing of human and animal health effects, organized by route, duration, and endpoint, is presented. Toxicological information on toxicokinetics, biomarkers, interactions, sensitive subpopulations, reducing toxicity after exposure, and relevance to public health is also included. Environmental information encompasses physical properties, production and use, environmental fate, levels seen in the environment, analytical methods, and a listing of regulations. ATSDR, at the behest of Congress and therefore the citizenry, prepares these profiles to inform the public about site contaminants.
邻苯二甲酸二（2-乙基己基）酯（也称为DEHP、双（2-乙基己基）邻苯二甲酸酯或BEHP；化学物质登记号117-81-7）是一种广泛使用的增塑剂。它存在于众多塑料制品中，如油漆、油墨、地砖、室内装饰品、浴帘、鞋类、塑料袋、食品包装材料、玩具和医用管材。不出所料，DEHP出现在许多垃圾场。作为其职责的一部分，有毒物质和疾病登记署（ATSDR）针对《综合环境反应、赔偿和责任法》（CERCLA）国家优先名录（NPL）场地中对公众健康影响最大的危险化学品编制毒理学概况。这些概况全面总结了毒理学和环境信息。本文将ATSDR关于DEHP的大部分概况（ATSDR，1993年）发布到主流科学文献中。文中按途径、持续时间和终点列出了广泛的人类和动物健康影响清单。还包括有关毒代动力学、生物标志物、相互作用、敏感亚群、接触后降低毒性以及与公众健康相关性的毒理学信息。环境信息包括物理性质、生产和用途、环境归宿、在环境中检测到的水平、分析方法以及法规清单。ATSDR应国会要求，因此也是应民众要求编制这些概况，以便向公众通报场地污染物情况。
