Sato H, Imagawa M, Kushiro K, Zakir M, Uchino Y
Department of Physiology, Tokyo Medical University, Japan.
Exp Brain Res. 2000 Apr;131(3):253-61. doi: 10.1007/s002219900309.
Convergence between posterior canal (PC) and saccular (SAC) inputs in single vestibular nuclei neurons was investigated in decerebrated cats. Postsynaptic potentials were recorded intracellularly after selective stimulation of the SAC and PC nerves. Stimulation of either the SAC or PC nerve orthodromically activated 143 vestibular nuclei neurons. Of these, 61 (43%) were antidromically activated by stimulation of the C1-C2 junction, 14 (10%) were antidromically activated by stimulation of the oculomotor or trochlear nucleus, and 14 (10%) were antidromically activated by stimulation of both the oculomotor or trochlear nucleus and the spinal cord. Fifty-four (38%) neurons were not activated by stimulation of either or both. We named these neurons vestibulospinal (VS), vestibulo-ocular (VO), vestibulooculo-spinal (VOS) and vestibular (V) neurons, respectively. Both PC and SAC inputs converged in 47 vestibular nuclei neurons (26 VS, 2 VO, 6 VOS and 13 V neurons). Of these, 19 received monosynaptic excitatory inputs from both nerves. This input pattern was frequently seen in VS neurons. Approximately half of the convergent VS neurons descended to the spinal cord through the lateral vestibulospinal tract. The remaining half and all the convergent VOS neurons descended to the spinal cord through the medial vestibulospinal tract. Most of the convergent neurons were located in the lateral nucleus or descending nucleus.
在去大脑的猫中研究了单个前庭核神经元后壶腹嵴（PC）和球囊（SAC）输入之间的汇聚情况。在选择性刺激SAC和PC神经后，细胞内记录突触后电位。顺向刺激SAC或PC神经可激活143个前庭核神经元。其中，61个（43%）可被刺激C1 - C2连接处逆向激活，14个（10%）可被刺激动眼神经或滑车神经核逆向激活，14个（10%）可被刺激动眼神经或滑车神经核以及脊髓逆向激活。54个（38%）神经元未被上述任何一种或两种刺激激活。我们分别将这些神经元命名为前庭脊髓（VS）、前庭眼（VO）、前庭眼脊髓（VOS）和前庭（V）神经元。PC和SAC输入在47个前庭核神经元（26个VS、2个VO、6个VOS和13个V神经元）中汇聚。其中，19个接受来自两条神经的单突触兴奋性输入。这种输入模式在VS神经元中很常见。大约一半的汇聚VS神经元通过外侧前庭脊髓束下行至脊髓。其余的一半以及所有汇聚的VOS神经元通过内侧前庭脊髓束下行至脊髓。大多数汇聚神经元位于外侧核或下行核。
