Zhang X, Sasaki M, Sato H, Meng H, Bai R S, Imagawa M, Uchino Y
Department of Physiology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan.
Exp Brain Res. 2002 Dec;147(3):407-17. doi: 10.1007/s00221-002-1273-8. Epub 2002 Oct 12.
The convergence between the anterior semicircular canal (AC) and utricular (UT) inputs, as well as the convergence between the AC and saccular (SAC) inputs in single vestibular neurons of decerebrated cats were investigated. Postsynaptic potentials were recorded intracellularly after selective stimulation of each pair of vestibular nerves AC/UT or AC/SAC. Neurons were recorded from the central parts of the vestibular nuclei, where the otolith afferents mainly terminate. Of a total of 105 neurons that were activated after stimulation of the AC and UT nerves, 42 received convergent inputs. Thirty-eight of these neurons received excitatory inputs from both afferents. Convergent neurons were further classified into vestibulospinal (n=28) and vestibulooculospinal (n=6) neurons by antidromic activation from the border between the C1 and C2 spinal cord and the oculomotor or trochlear nucleus. Eight neurons that were not antidromically activated from either site were classified as vestibular neurons. Forty three percent of the convergent vestibulospinal neurons and most of the convergent vestibulooculospinal neurons projected to the spinal cord through the medial vestibulospinal tract. The remaining vestibulospinal and vestibulooculospinal neurons descended through the ipsilateral lateral vestibulospinal tract. Of a total of 118 neurons that were activated after stimulation of the AC and/or SAC nerves, 51 received convergent inputs (27 vestibulospinal, 4 vestibulooculospinal, 5 vestibuloocular and 15 vestibular neurons). Forty-two of the convergent neurons received excitatory inputs from both afferents. Thirty seven percent of the convergent vestibulospinal neurons and all of the convergent vestibulooculospinal neurons projected to the spinal cord through the medial vestibulospinal tract. The remaining vestibulospinal and vestibulooculospinal neurons descended through the ipsilateral lateral vestibulospinal tract.
研究了去大脑猫单个前庭神经元中前半规管（AC）与椭圆囊（UT）输入之间的汇聚，以及AC与球囊（SAC）输入之间的汇聚。在选择性刺激每对前庭神经AC/UT或AC/SAC后，细胞内记录突触后电位。从前庭核的中央部分记录神经元，耳石传入纤维主要在此终止。在刺激AC和UT神经后被激活的总共105个神经元中，42个接受汇聚输入。这些神经元中有38个从两种传入纤维都接受兴奋性输入。通过来自C1和C2脊髓边界以及动眼神经或滑车神经核的逆向激活，将汇聚神经元进一步分为前庭脊髓（n = 28）和前庭眼脊髓（n = 6）神经元。8个未从任何一个部位被逆向激活的神经元被分类为前庭神经元。43%的汇聚前庭脊髓神经元和大多数汇聚前庭眼脊髓神经元通过内侧前庭脊髓束投射到脊髓。其余的前庭脊髓和前庭眼脊髓神经元通过同侧外侧前庭脊髓束下行。在刺激AC和/或SAC神经后被激活的总共118个神经元中，51个接受汇聚输入（27个前庭脊髓、4个前庭眼脊髓、5个前庭眼和15个前庭神经元）。42个汇聚神经元从两种传入纤维都接受兴奋性输入。37%的汇聚前庭脊髓神经元和所有汇聚前庭眼脊髓神经元通过内侧前庭脊髓束投射到脊髓。其余的前庭脊髓和前庭眼脊髓神经元通过同侧外侧前庭脊髓束下行。
