Maurizi C P
Department of Pathology, Houston Medical Center, Warner Robins, GA 31093, USA.
Med Hypotheses. 2000 Jan;54(1):26-9. doi: 10.1054/mehy.1998.0812.
Speculation about mania links melatonin, vasotocin and rapid-eye-movement (REM) sleep. Normal REM sleep can have the loss of reality testing and this feature intruding into the wake period could be the cause of the distorted reality present in manic delusions. REM sleep has a role in memory formation. Abnormal levels and/or rhythms of melatonin are thought to be involved in mania. Decreased melatonin production with malfunction of REM sleep is proposed to be a cause of sudden infant death syndrome and Alzheimer's disease, because the loss of the antioxidant function of melatonin allows brain injury to occur.
关于躁狂症的推测将褪黑素、血管加压素和快速眼动（REM）睡眠联系在一起。正常的快速眼动睡眠可能会出现现实检验能力缺失，而这种特征侵入清醒期可能是躁狂妄想中存在的现实扭曲的原因。快速眼动睡眠在记忆形成中起作用。褪黑素水平和/或节律异常被认为与躁狂症有关。有人提出，快速眼动睡眠功能失调导致褪黑素分泌减少是婴儿猝死综合征和阿尔茨海默病的一个原因，因为褪黑素抗氧化功能的丧失会导致脑损伤。
