Drapkina O M, Zadorozhnaia O O, Ivashkin V T, Manukhina E B, Malyshev I Iu
Klin Med (Mosk). 2000;78(3):19-23.
The findings of the author demonstrate that the system of nitric oxide (NO) generation and metabolism is an element of multicomponent response of the organism to myocardial infarction (MI). This response consists in MI patients' systemic ability and, in particular, their peripheral blood mononuclears' ability to produce NO as well as the absence of iNOS activation in peripheral blood of MI patients. It is important for a practitioner to understand that a fall in the urine and plasma concentration of NO metabolism end product reflects low activity of NO generation while NO is a powerful regulatory factor in the cardiovascular system. Thus, low levels of NO and its metabolites in the urine and plasma of MI patients indicate depletion of compensatory coronarodilatating potential and, eventually, poor prognosis. Relevant measurements will provide additional parameters in assessment of body reserves in MI patients and in MI prognosis within the first hours of its onset.
作者的研究结果表明，一氧化氮（NO）生成和代谢系统是机体对心肌梗死（MI）多组分反应的一个要素。这种反应表现为MI患者的全身能力，尤其是其外周血单核细胞产生NO的能力，以及MI患者外周血中诱导型一氧化氮合酶（iNOS）未被激活。从业者必须明白，NO代谢终产物在尿液和血浆中的浓度下降反映了NO生成活性较低，而NO是心血管系统中一种强大的调节因子。因此，MI患者尿液和血浆中NO及其代谢产物水平较低表明其冠状动脉扩张的代偿潜力耗尽，最终预后不良。相关测量将为评估MI患者发病后最初几小时内的身体储备和MI预后提供额外参数。
