Blackmore-Prince C, Kieke B, Kugaraj K A, Ferré C, Elam-Evans L D, Krulewitch C J, Gaudino J A, Overpeck M
Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Matern Child Health J. 1999 Dec;3(4):189-97. doi: 10.1023/a:1022373205005.
To determine if the association between race and preterm delivery would persist when preterm delivery was partitioned into two etiologic pathways.
We evaluated perinatal and obstetrical data from the 1988 National Maternal and Infant Health Survey and classified preterm delivery as spontaneous or medically indicated. Discrete proportional hazard models were fit to assess the risk of preterm delivery for Black women compared with White women adjusting for potential demographic and behavioral confounding variables.
Preterm delivery occurred among 17.4% of Black births and 6.7% of White births with a Black versus White unadjusted hazard ratio (HR) of 2.8 (95% CI = 2.4-3.3). The adjusted HR for a medically indicated preterm delivery showed no racial difference in risk (HR = 1.0, 95% CI = 0.4-2.6). However, for spontaneous preterm delivery between 20 and 28 weeks gestation, the Black versus White adjusted hazard ratio (HR) was 4.9 (95% CI = 3.4-7.1).
Although we found an increased unadjusted HR for preterm delivery among Black women compared with White women, the nearly fivefold increase in adjusted HR for the extremely preterm births and the absence of a difference for medically indicated preterm delivery was unexpected. Given the differences in the risks of preterm birth between Black and White women, we recommend to continue examining risk factors for preterm delivery after separating spontaneous from medically indicated preterm birth and subdividing preterm delivery by gestational age to shed light on the reasons for the racial disparity.
当将早产分为两种病因途径时,确定种族与早产之间的关联是否仍然存在。
我们评估了1988年全国母婴健康调查中的围产期和产科数据,并将早产分类为自发性或医学指征性。采用离散比例风险模型来评估黑人女性与白人女性相比早产的风险,并对潜在的人口统计学和行为混杂变量进行了调整。
黑人出生中早产发生率为17.4%,白人出生中早产发生率为6.7%,黑人与白人未调整的风险比(HR)为2.8(95%可信区间=2.4-3.3)。医学指征性早产的调整后HR显示风险无种族差异(HR=1.0,95%可信区间=0.4-2.6)。然而,对于妊娠20至28周的自发性早产,黑人与白人的调整后风险比(HR)为4.9(95%可信区间=3.4-7.1)。
尽管我们发现黑人女性与白人女性相比,未调整的早产HR有所增加,但极早产调整后HR增加近五倍以及医学指征性早产无差异这一情况出乎意料。鉴于黑人和白人女性早产风险存在差异,我们建议在将自发性早产与医学指征性早产后,并按孕周细分早产情况后,继续研究早产的风险因素,以阐明种族差异的原因。