Gavin Amelia R, Chae David H, Mustillo Sarah, Kiefe Catarina I
University of Washington, School of Social Work, 4101 15th Avenue NE, Seattle, WA 98105, USA.
J Womens Health (Larchmt). 2009 Jun;18(6):803-11. doi: 10.1089/jwh.2008.0984.
We examine associations among race, prepregnancy depressive mood, and preterm birth (<37 weeks gestation) in a cohort study of black and white women.
We tested for mediation of the association between race and preterm birth by prepregnancy depressive mood among 555 women enrolled in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.
Black women had significantly higher levels of prepregnancy depressive mood (modified CES-D score 13.0 vs. 9.5, t = -4.64, p < 0.001). After adjustment for covariates, black women had 2.70 times the odds of preterm birth as white women (95% confidence interval [CI] 1.41, 5.17). When adding prepregnancy depressive mood to this model, higher depressive mood was associated with greater odds of preterm birth (odds ratio [OR] 1.04; 95% CI 1.01, 1.07), and the effect of black race was attenuated (OR 2.47, 95% CI 1.28, 4.77).
Our data suggest that prepregnancy depressive mood may be a risk factor for preterm birth among black and white women.
在一项针对黑人和白人女性的队列研究中，我们探讨种族、孕前抑郁情绪与早产（妊娠<37周）之间的关联。
在参与“青年成人冠状动脉风险发展研究”（CARDIA研究）的555名女性中，我们检验了孕前抑郁情绪对种族与早产之间关联的中介作用。
黑人女性孕前抑郁情绪水平显著更高（改良CES-D评分13.0对9.5，t = -4.64，p < 0.001）。在对协变量进行调整后，黑人女性早产的几率是白人女性的2.70倍（95%置信区间[CI] 1.41, 5.17）。当将孕前抑郁情绪加入该模型时，较高的抑郁情绪与早产几率增加相关（优势比[OR] 1.04；95% CI 1.01, 1.07），并且黑人种族的影响减弱（OR 2.47, 95% CI 1.28, 4.77）。
我们的数据表明，孕前抑郁情绪可能是黑人和白人女性早产的一个风险因素。
