原发性皮肤CD30+间变性大细胞淋巴瘤一例中的CD56表达

CD56 expression in a case of primary cutaneous CD30+ anaplastic large cell lymphoma.

作者信息

Chang S E, Park I J, Huh J, Choi J H, Sung K J, Moon K C, Koh J K

机构信息

Departments of Dermatology and Pathology, Asan Medical Center, College of Medicine, University of Ulsan, 388-1 Poongnap-Dong, Songpa-Gu, Seoul 138-736, Korea.

出版信息

Br J Dermatol. 2000 Apr;142(4):766-70. doi: 10.1046/j.1365-2133.2000.03423.x.

DOI:10.1046/j.1365-2133.2000.03423.x

PMID:10792229

Abstract

We describe clinicopathological features of an unusual case of CD30+/CD56+ T-cell lymphoma in a 58-year-old Korean man who presented with disseminated nodules, papules and hyperpigmented patches. Coexpression of CD30 and CD56 in T-cell lymphoma is very rare. Our patient did not respond to an intensive chemotherapy regimen, in contrast to the previously reported cases of primary cutaneous CD30+ anaplastic large cell lymphoma. Coexpression of CD56 might therefore identify a subset of CD30+ lymphomas with more aggressive features.

摘要

我们描述了一名58岁韩国男性的罕见病例，其患有CD30+/CD56+ T细胞淋巴瘤，表现为弥漫性结节、丘疹和色素沉着斑。T细胞淋巴瘤中CD30和CD56的共表达非常罕见。与先前报道的原发性皮肤CD30+间变性大细胞淋巴瘤病例不同，我们的患者对强化化疗方案无反应。因此，CD56的共表达可能识别出具有更侵袭性特征的CD30+淋巴瘤亚组。