Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Ophthalmology. 2010 Feb;117(2):343-51. doi: 10.1016/j.ophtha.2009.07.013. Epub 2009 Dec 6.
To report the clinicopathologic features of 3 patients with CD30(+) lymphoid proliferations of the eyelid.
Retrospective case series.
Patients with cutaneous CD30(+) lymphoproliferative lesions of the eyelid.
Three patients with CD30(+) non-mycosis fungoides T-cell lymphoid infiltrates of the eyelid were identified. The histories, clinical findings, pathologic features including immunohistochemical staining, treatments, and outcomes were reviewed and compared.
Pathologic findings including immunohistochemical analysis.
The patients included an 81-year-old man, an 18-year-old man, and a 42-year-old woman with CD30(+) lymphoid proliferations of the eyelid and adjacent soft tissue. The first patient had an isolated crateriform eyelid lesion that was classified as lymphomatoid papulosis (LyP). The second patient had an isolated multinodular lesion of the eyelid that was classified as cutaneous anaplastic large cell lymphoma (cALCL). The third patient presented with eyelid edema with an underlying mass and was found to have widely disseminated anaplastic large cell lymphoma (ALCL). Diagnoses were dependent on clinical findings.
The CD30(+) lymphoid proliferations represent a spectrum of conditions ranging from indolent LyP, to moderately aggressive cALCL, to highly aggressive ALCL. Interpretation of the pathologic findings in CD30(+) lymphoid proliferations is based in part on clinical findings.
FINANCIAL DISCLOSURE(S): The authors have no proprietary or commercial interest in any material discussed in this article.
报告 3 例眼睑 CD30(+)淋巴增生的临床病理特征。
回顾性病例系列。
眼睑皮肤 CD30(+)淋巴增生性病变患者。
确定了 3 例眼睑 CD30(+)非蕈样真菌病 T 细胞淋巴浸润的患者。回顾并比较了病史、临床发现、病理特征，包括免疫组织化学染色、治疗和结果。
病理发现，包括免疫组织化学分析。
患者包括 1 例 81 岁男性、1 例 18 岁男性和 1 例 42 岁女性，他们的眼睑和邻近软组织均存在 CD30(+)淋巴增生。第 1 例患者有孤立性火山口状眼睑病变，被归类为淋巴瘤样丘疹病（LyP）。第 2 例患者有孤立性多结节性眼睑病变，被归类为皮肤间变性大细胞淋巴瘤（cALCL）。第 3 例患者表现为眼睑水肿伴下方肿块，被发现患有广泛播散性间变性大细胞淋巴瘤（ALCL）。诊断依赖于临床发现。
CD30(+)淋巴增生代表了一系列疾病，从惰性 LyP 到中度侵袭性 cALCL 再到高度侵袭性 ALCL。CD30(+)淋巴增生的病理发现的解读部分基于临床发现。
作者在本文讨论的任何材料中均无专有或商业利益。
