Perazella M A, Eras J
Department of Internal Medicine, Section of Nephrology, Yale University School of Medicine, New Haven, CT 06520, USA.
Am J Kidney Dis. 2000 May;35(5):937-40. doi: 10.1016/s0272-6386(00)70266-6.
Nonsteroidal anti-inflammatory drugs are well-known culprits in the development of acute renal insufficiency in high-risk patients. The recent release of the selective cyclooxygenase-2 enzyme inhibitors for the treatment of inflammatory diseases and pain syndromes has been associated with a clear-cut decrease in adverse gastrointestinal effects. However, the nephrotoxic potential of these agents in patients with prostaglandin-dependent states and chronic renal impairment is unknown. Many clinicians commonly wonder if these agents can be safely prescribed to such high-risk patients. We present two cases of acute renal failure complicating the course of therapy with celecoxib in patients with chronic renal insufficiency.
非甾体抗炎药是高危患者发生急性肾功能不全的常见原因。最近用于治疗炎症性疾病和疼痛综合征的选择性环氧化酶-2酶抑制剂的问世，已使不良胃肠道反应明显减少。然而，这些药物在前列腺素依赖状态和慢性肾功能损害患者中的肾毒性潜力尚不清楚。许多临床医生常常想知道这些药物能否安全地用于此类高危患者。我们报告两例慢性肾功能不全患者在使用塞来昔布治疗过程中并发急性肾衰竭的病例。
