血管内皮生长因子（VEGF）诱导的视网膜血管通透性是由细胞间黏附分子-1（ICAM-1）介导的。
Vascular endothelial growth factor (VEGF)-induced retinal vascular permeability is mediated by intercellular adhesion molecule-1 (ICAM-1).
作者信息
Miyamoto K, Khosrof S, Bursell S E, Moromizato Y, Aiello L P, Ogura Y, Adamis A P
机构信息
Laboratory for Surgical Research, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Am J Pathol. 2000 May;156(5):1733-9. doi: 10.1016/S0002-9440(10)65044-4.
Abstract
Two prominent vascular endothelial growth factor (VEGF)-induced retinal effects are vascular permeability and capillary nonperfusion. The mechanisms by which these effects occur are not completely known. Using a rat model, we show that intravitreous injections of VEGF precipitate an extensive retinal leukocyte stasis (leukostasis) that coincides with enhanced vascular permeability and capillary nonperfusion. The leukostasis is accompanied by the up-regulation of intercellular adhesion molecule-1 expression in the retina. The inhibition of intercellular adhesion molecule-1 bioactivity with a neutralizing antibody prevents the permeability and leukostasis increases by 79% and 54%, respectively. These data are the first to demonstrate that a nonendothelial cell type contributes to VEGF-induced vascular permeability. Additionally, they identify a potential mechanism for VEGF-induced retinal capillary nonperfusion.
摘要
血管内皮生长因子（VEGF）诱导的两种显著视网膜效应是血管通透性增加和毛细血管无灌注。这些效应产生的机制尚不完全清楚。我们利用大鼠模型表明，玻璃体内注射VEGF会引发广泛的视网膜白细胞停滞（白细胞淤滞），这与血管通透性增强和毛细血管无灌注同时出现。白细胞淤滞伴随着视网膜中细胞间黏附分子-1表达上调。用中和抗体抑制细胞间黏附分子-1的生物活性可分别使通透性和白细胞淤滞增加减少79%和54%。这些数据首次证明非内皮细胞类型促成了VEGF诱导的血管通透性增加。此外，它们还确定了VEGF诱导视网膜毛细血管无灌注的一种潜在机制。
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