胸腺来源的大鼠细胞表面抗原淋巴细胞受体是主要组织相容性基因复合体的一种非血清学定义产物。

Thymus-derived rat lymphocyte receptor for cell surface antigens is a nonserologically defined product of the major histocompatibility gene complex.

作者信息

Wekerle H, Eshhar Z, Lonai P, Feldman M

出版信息

Proc Natl Acad Sci U S A. 1975 Mar;72(3):1147-51. doi: 10.1073/pnas.72.3.1147.

DOI:10.1073/pnas.72.3.1147

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC432483/

Abstract

Recognition of cell surface antigens by nonsensitized thymus-derived rat lymphocytes is not affected by antisera against immunoglobulin, yet can be effectively blocked by treatment of the lymphocytes with alloantisera raised against lymphoid cells. However, allo antisera induced by nonlymphoid cells do not inhibit recognition. Adsorption of blocking antisera on immunoglobulin-Sepharose columns does not decrease their blocking activity. Absorption of blocking alloantisera with liver and kidney homogenates removes the cytotoxic alloantibodies, yet does not affect the capacity of the antisera to block recognition. Anti-H1-1 alloantisera block antigen recognition only of lymphocytes of strains that share the H1-1 locus. These results suggest that the constant part of the thymus-derived lymphocyte receptor for cell-surface antigens is a product of the rat major histocompatibility locus, which is not identical with the serologically defined antigens.

摘要

未致敏的大鼠胸腺来源淋巴细胞对细胞表面抗原的识别不受抗免疫球蛋白抗血清的影响，但用针对淋巴细胞产生的同种抗血清处理淋巴细胞后，其识别可被有效阻断。然而，由非淋巴细胞诱导产生的同种抗血清并不抑制识别。将阻断抗血清吸附于免疫球蛋白 - 琼脂糖柱上不会降低其阻断活性。用肝和肾匀浆吸收阻断同种抗血清可去除细胞毒性同种抗体，但不影响抗血清阻断识别的能力。抗H1 - 1同种抗血清仅阻断具有H1 - 1位点的品系淋巴细胞的抗原识别。这些结果表明，胸腺来源淋巴细胞的细胞表面抗原受体的恒定部分是大鼠主要组织相容性位点的产物，它与血清学定义的抗原不同。

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Immunology. 1969 May;16(5):643-57.

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