Coceani F, Viti A
Can J Physiol Pharmacol. 1975 Apr;53(2):273-84. doi: 10.1139/y75-039.
Prostaglandin E1 (PGE1) has been tested by microiontophoresis on interneurons and motoneurons in the isolated spinal cord of the frog. PGE1 action was almost exclusively excitatory, regardless of the cell type and the test condition used. In general, the excitatory response had rapid onset and termination, and was susceptible to tachyphylaxis. Responsive interneurons were scattered throughout the tissue, and the incidence of responses showed no obvious relation to the mono- vs. polysynaptic connection of cells to primary afferents and descending fibers of the lateral funiculus. PGE1-sensitive interneurons were encountered more often in preparations from summer than from winter animals. These findings, coupled with the demonstration of prostaglandin biosynthesis and catabolism in the tissue, suggest that PGE1 plays a role in the normal function of spinal neurons. The intimate mechanism of PGE1 action remains to be elucidated.
前列腺素E1（PGE1）已通过微离子透入法在青蛙离体脊髓的中间神经元和运动神经元上进行了测试。无论细胞类型和所采用的测试条件如何，PGE1的作用几乎完全是兴奋性的。一般来说，兴奋性反应起效快且终止快，并且容易产生快速耐受性。反应性中间神经元分散在整个组织中，反应发生率与细胞与初级传入纤维和外侧索下行纤维的单突触与多突触连接无明显关系。在夏季动物的制备物中比在冬季动物的制备物中更常遇到对PGE1敏感的中间神经元。这些发现，再加上组织中前列腺素生物合成和分解代谢的证明，表明PGE1在脊髓神经元的正常功能中起作用。PGE1作用的具体机制仍有待阐明。
