淋巴细胞对植物凝集素的反应。I. 对商陆有丝分裂原产生反应的胸腺依赖性淋巴细胞群体。
Response of lymphocytes to plant lectins. I. A thymic-dependent lymphoid population responsive to pokeweed mitogen.
作者信息
Weksler M E, Bodine S, Rommer J
出版信息
Immunology. 1974 Feb;26(2):281-90.
The response of lymph node, bone marrow, splenic and thymic lymphocytes to phytohaemagglutinin and Pokeweed mitogen has been studied. Depletion of theta positive or recirculating lymphocytes abolished the response to phytohaemagglutinin but did not impair the response to Pokeweed mitogen. Lymphocytes from thymectomized or athymic `nude' mice respond poorly or not at all to phytohaemagglutinin or Pokeweed mitogen. We conclude that the normal response to Pokeweed mitogen depends upon an intact thymus gland. This despite the fact that one population of Pokeweed mitogen-responsive cells are theta-negative bone marrow-derived cells. This conclusion is based upon: (1) the equal reactivity of theta-positive and theta-negative lymphocytes to Pokeweed mitogen as shown by the normal response to Pokeweed mitogen of anti-theta serum treated lymphoid populations and (2) the impaired response of lymphocytes from nude mice and of lymphocytes from thymectomized, irradiated and bone marrow reconstituted mice to Pokeweed mitogen.
研究了淋巴结、骨髓、脾脏和胸腺淋巴细胞对植物血凝素和商陆有丝分裂原的反应。去除θ阳性或再循环淋巴细胞可消除对植物血凝素的反应，但不损害对商陆有丝分裂原的反应。来自胸腺切除或无胸腺“裸”鼠的淋巴细胞对植物血凝素或商陆有丝分裂原反应不佳或根本无反应。我们得出结论，对商陆有丝分裂原的正常反应依赖于完整的胸腺。尽管事实上一群对商陆有丝分裂原反应的细胞是θ阴性骨髓来源的细胞。这一结论基于：（1）抗θ血清处理的淋巴细胞群体对商陆有丝分裂原的正常反应表明，θ阳性和θ阴性淋巴细胞对商陆有丝分裂原的反应相同；（2）裸鼠淋巴细胞以及胸腺切除、照射和骨髓重建小鼠的淋巴细胞对商陆有丝分裂原的反应受损。
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