Basílio-De-Oliveira C A
Department of Pathology, Gaffrée and Guinle University Hospital, University of Rio de Janeiro (Uni-Rio), Rio de Janeiro, RJ, Brazil.
Braz J Infect Dis. 2000 Apr;4(2):67-75.
The course of human immunodeficiency virus infection and the acquired immunodeficiency syndrome can be complicated by a variety of endocrine abnormalities. This article describes the findings of a prospective autopsy study of the thyroid in 100 patients who died of complications of AIDS before the advent of the so-called highly active antiretroviral therapy [corrected]. A wide range of bacterial, fungal, viral, and neoplastic disorders were observed. Mycobacterium tuberculosis was recorded in 23% of the patients, cytomegalovirus in 17%, Cryptococcus in 5%, Mycobacterium avium in 5%, Pneumocystis in 4%, and other bacteria or fungi in 7%. Kaposi's sarcoma was recorded in 2% of patients and occult papillary carcinoma in 4%. Four patients had dual infections of the thyroid. The mean weight of the thyroid was lower than normal, and 1 case of thyroid follicular atrophy is presented. A review of the medical literature on thyroid disorders in HIV-infected patients is included. Physicians caring for HIV patients should be aware of the possibility of thyroid dysfunction in their patients.
人类免疫缺陷病毒感染及获得性免疫缺陷综合征的病程可能会因多种内分泌异常而变得复杂。本文描述了一项前瞻性尸检研究的结果，该研究对100例在所谓的高效抗逆转录病毒治疗出现之前死于艾滋病并发症的患者的甲状腺进行了研究。观察到了广泛的细菌、真菌、病毒和肿瘤性疾病。23%的患者记录有结核分枝杆菌，17%有巨细胞病毒，5%有隐球菌，5%有鸟分枝杆菌，4%有肺孢子菌，7%有其他细菌或真菌。2%的患者记录有卡波西肉瘤，4%有隐匿性乳头状癌。4例患者的甲状腺有双重感染。甲状腺的平均重量低于正常，文中展示了1例甲状腺滤泡萎缩的病例。本文还包括了对关于HIV感染患者甲状腺疾病的医学文献的综述。照料HIV患者的医生应意识到其患者出现甲状腺功能障碍的可能性。
