Pearlstein T
Department of Psychiatry and Human Behavior, Butler Hospital, Brown University School of Medicine, Providence, RI 02906, USA.
J Clin Psychiatry. 2000;61 Suppl 7:40-3.
Recent large double-blind, placebo-controlled trials have indicated that sertraline is an effective and well-tolerated treatment for posttraumatic stress disorder (PTSD). The avoidance/numbing symptom cluster improved the most significantly with sertraline, but significant improvements were also noted for the intrusive/reexperiencing and arousal symptom clusters. Smaller double-blind, placebo-controlled trials have also indicated that fluoxetine is an effective treatment for PTSD. Multiple small, open studies with other selective serotonin reuptake inhibitors and newer antidepressants indicate that these medications show some promise. Older studies indicate some efficacy for tricyclic antidepressants, and monoamine oxidase inhibitors are a reasonable choice, particularly for intrusive/reexperiencing symptoms.
近期大规模双盲、安慰剂对照试验表明，舍曲林是治疗创伤后应激障碍（PTSD）的一种有效且耐受性良好的药物。使用舍曲林治疗时，回避/麻木症状群改善最为显著，但侵入性/再体验症状群和觉醒症状群也有显著改善。规模较小的双盲、安慰剂对照试验也表明，氟西汀是治疗PTSD的有效药物。多项针对其他选择性5-羟色胺再摄取抑制剂和新型抗抑郁药的小型开放性研究表明，这些药物显示出一定前景。早期研究表明三环类抗抑郁药有一定疗效，单胺氧化酶抑制剂是合理选择，尤其适用于侵入性/再体验症状。
