Chiang H, Sirois D A, Bielory L
University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103, USA.
Ann Allergy Asthma Immunol. 2000 Apr;84(4):391-5. doi: 10.1016/S1081-1206(10)62270-3.
Pemphigus vulgaris most often begins in the mouth but is often overlooked in the differential diagnosis of chronic, multiple oral ulcerations and erosions. Accurate diagnosis requires perilesional biopsy including intact epithelium, submitted for hematoxylin and eosin as well as direct immunofluorescence staining. Early and aggressive treatment with moderate to high dose prednisone in combination with steroid sparing drugs such as azathioprine and mycophenolate allow complete remission in most patients.
寻常型天疱疮最常始于口腔，但在慢性多发性口腔溃疡和糜烂的鉴别诊断中常被忽视。准确诊断需要进行病损周围活检，包括完整的上皮组织，送苏木精-伊红染色以及直接免疫荧光染色检查。早期积极采用中高剂量泼尼松联合硫唑嘌呤和霉酚酸酯等激素节省药物进行治疗，可使大多数患者完全缓解。
