Makrides M, Crowther C A
Women's and Children's Hospital, Obstetrics and Gynaecology, University of Adelaide, 72 King William Road, North Adelaide, SA, Australia, 5006.
Cochrane Database Syst Rev. 2000(2):CD000937. doi: 10.1002/14651858.CD000937.
Many women, especially those from disadvantaged backgrounds, have intakes of magnesium below recommended levels. Magnesium supplementation during pregnancy may be able to reduce fetal growth retardation and pre-eclampsia, and increase birthweight.
The objective of this review was to assess the effects of magnesium supplementation during pregnancy on maternal, neonatal and paediatric outcomes.
We searched the Cochrane Pregnancy and Childbirth Group trials register.
Randomised and quasi-randomised trials of dietary magnesium supplementation during pregnancy.
Suitability for inclusion and methodological quality were separately assessed by each reviewer. Data were independently extracted by two reviewers.
Six trials involving 2637 women were included. Only one of these trials was judged to be of high quality. Compared with placebo, oral magnesium treatment from before the 25th week of gestation was associated with a lower incidence of preterm birth (odds ratio 0.71, 95% confidence interval 0.52 to 0.95). There was also less maternal hospitalisation during pregnancy, fewer cases of antepartum haemorrhage, a lower incidence of low birthweight and small for gestational age infants. Poor quality trials are likely to have resulted in a bias favouring magnesium supplementation.
REVIEWER'S CONCLUSIONS: There is not enough high quality evidence to show that dietary magnesium supplementation during pregnancy is beneficial.
许多女性，尤其是那些来自弱势背景的女性，镁摄入量低于推荐水平。孕期补充镁可能能够减少胎儿生长受限和先兆子痫，并增加出生体重。
本综述的目的是评估孕期补充镁对孕产妇、新生儿和儿童结局的影响。
我们检索了Cochrane妊娠与分娩组试验注册库。
孕期膳食补充镁的随机和半随机试验。
每位综述作者分别评估纳入的适宜性和方法学质量。数据由两名综述作者独立提取。
纳入了6项涉及2637名女性的试验。其中只有1项试验被判定为高质量。与安慰剂相比，妊娠25周前开始口服镁治疗与早产发生率较低相关（比值比0.71，95%置信区间0.52至0.95）。孕期孕产妇住院次数也较少，产前出血病例较少，低出生体重和小于胎龄儿的发生率较低。质量较差的试验可能导致了有利于补充镁的偏倚。
没有足够的高质量证据表明孕期膳食补充镁有益。
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