Jepson R G, Mihaljevic L, Craig J
15 Blackwood Crescent, Edinburgh, UK, EH9 1QZ.
Cochrane Database Syst Rev. 2000;1998(2):CD001322. doi: 10.1002/14651858.CD001322.
Cranberries (particularly in the form of cranberry juice) have been used widely for several decades for the prevention and treatment of urinary tract infections. The aim of this review is to assess the effectiveness of cranberries in treating such infections.
To assess the effectiveness of cranberries for the treatment of urinary tract infections.
The search strategy developed by the Cochrane Renal Group was used. Also, companies involved with the promotion and distribution of cranberry preparations were contacted; electronic databases and the Internet were searched using English and non English language terms; reference lists of review articles and relevant trials were also searched.
All randomised or quasi randomised controlled trials of cranberry juice or cranberry products for the treatment of urinary tract infections. Trials of men, women or children were included.
Titles and abstracts of studies that were potentially relevant to the review were screened by one reviewer, RJ, who discarded studies that were clearly ineligible but aimed to be overly inclusive rather than risk losing relevant studies. Reviewers RJ and LM independently assessed whether the studies met the inclusion criteria. Further information was sought from the authors where papers contained insufficient information to make a decision about eligibility.
No trials were found which fulfilled all of the inclusion criteria. Two trials were excluded because they did not have any relevant outcomes.
REVIEWER'S CONCLUSIONS: After a thorough search, no randomised trials which assessed the effectiveness of cranberry juice for the treatment of urinary tract infections were found. Therefore, at the present time, there is no good quality evidence to suggest that it is effective for the treatment of urinary tract infections. Well-designed parallel group, double blind trials comparing cranberry juice and other cranberry products versus placebo to assess the effectiveness of cranberry juice in treating urinary tract infections are needed. Outcomes should include reduction in symptoms, sterilisation of the urine, side effects and adherence to therapy. Dosage (amount and concentration) and duration of therapy should also be assessed. Consumers and clinicians will welcome the evidence from these trials.
蔓越莓（尤其是蔓越莓汁形式）数十年来已被广泛用于预防和治疗尿路感染。本综述的目的是评估蔓越莓在治疗此类感染方面的有效性。
评估蔓越莓治疗尿路感染的有效性。
采用Cochrane肾脏组制定的检索策略。此外，还联系了参与蔓越莓制剂推广和销售的公司；使用英语和非英语术语搜索电子数据库和互联网；还检索了综述文章和相关试验的参考文献列表。
所有关于蔓越莓汁或蔓越莓产品治疗尿路感染的随机或半随机对照试验。纳入男性、女性或儿童的试验。
由一位评审员RJ筛选可能与综述相关的研究的标题和摘要，RJ摒弃明显不符合条件的研究，但旨在过度包容而非冒着遗漏相关研究的风险。评审员RJ和LM独立评估研究是否符合纳入标准。如果论文包含的信息不足以决定其是否符合条件，则向作者寻求更多信息。
未发现符合所有纳入标准的试验。两项试验被排除，因为它们没有任何相关结果。
经过全面检索，未找到评估蔓越莓汁治疗尿路感染有效性的随机试验。因此，目前没有高质量证据表明其对治疗尿路感染有效。需要设计良好的平行组、双盲试验，比较蔓越莓汁和其他蔓越莓产品与安慰剂，以评估蔓越莓汁治疗尿路感染的有效性。结果应包括症状减轻、尿液灭菌、副作用和治疗依从性。还应评估治疗的剂量（数量和浓度）和持续时间。消费者和临床医生将欢迎这些试验的证据。
