Bachoo P, Brazzelli M, Grant A
Health Services Research Unit, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, Aberdeenshire, UK, AB25 2ZD.
Cochrane Database Syst Rev. 2000(2):CD001757. doi: 10.1002/14651858.CD001757.
Faecal incontinence is a debilitating problem with significant medical, social and economic implications. Treatment options include conservative, non-operative interventions (e.g. pelvic floor muscle training, biofeedback, drugs) and surgical procedures. Surgery is used in selected groupsof people when the structural and functional defects in the pelvic floor muscles or the anal sphincter complex can be corrected mechanically.
To assess the effects of established surgical techniques for the treatment of faecal incontinence in adults who do not have rectal prolapse. Our aims were firstly to compare surgical management with non-surgical management and secondly, to compare the various surgical techniques.
We searched the Cochrane Incontinence Group trials register, the Cochrane Colorectal Cancer Group trials register, the Cochrane Controlled Trials Register (Issue 2, 1999), Medline (up to March 1999), Embase (1998 up to January 1999), Sigle (1980 up to December 1996), Biosis (1998 up to March 1999), SCI (1998 up to March 1999), ISTP (1982 up to March 1999) and the reference lists of relevant articles. We specifically hand searched the British Journal of Surgery from 1995 to 1998 and the Diseases of the Colon and Rectum from 1995 to 1998. We also perused the proceedings of the Association of Coloproctology, meeting 1999. Date of the most recent literature searches: March 1999.
All randomised or quasi-randomised trials of surgery in the management of adult faecal incontinence (other then surgery for rectal prolapse).
Two reviewers independently selected studies from the literature, extracted data and assessed the methodological quality of eligible trials. The three primary outcome measures were: change or deterioration in incontinence, failure to achieve full continence, and the presence of faecal urgency.
Four trials were included with a total sample size of 110 participants. All trials excluded women with anal sphincter defects detected by endoanal ultrasound examination. No trial included a group managed non-surgically. Two trials (56 participants) compared three approaches to pelvic floor repair (anterior levatorplasty, postanal repair and their combination total pelvic floor repair). One trial (30 participants) evaluated adding plication of the anal sphincter to total pelvic floor repair. The fourth trial (24 participants) compared a neosphincter procedure with total pelvic floor repair. No differences in the primary outcomes were detected, but data were few and inconsistently reported.
REVIEWER'S CONCLUSIONS: The small number of relevant trials identified together with their small sample sizes and other methodological weaknesses severely limit the usefulness of this review for guiding practice. It was impossible to identify or refute clinically important differences between the alternative surgical procedures. Larger rigorous trials are needed.
大便失禁是一个使人衰弱的问题,具有重大的医学、社会和经济影响。治疗选择包括保守的非手术干预措施(如盆底肌训练、生物反馈、药物)和外科手术。当盆底肌肉或肛门括约肌复合体的结构和功能缺陷能够通过机械手段纠正时,手术适用于特定人群。
评估已确立的手术技术对无直肠脱垂的成年人大便失禁的治疗效果。我们的目的一是比较手术治疗与非手术治疗,二是比较各种手术技术。
我们检索了Cochrane尿失禁组试验注册库、Cochrane结直肠癌组试验注册库、Cochrane对照试验注册库(1999年第2期)、Medline(截至1999年3月)、Embase(1998年至1999年1月)、Sigle(1980年至1996年12月)、Biosis(1998年至1999年3月)、SCI(1998年至1999年3月)、ISTP(1982年至1999年3月)以及相关文章的参考文献列表。我们专门手工检索了1995年至1998年的《英国外科学杂志》和1995年至1998年的《结肠和直肠疾病》。我们还查阅了1999年结肠直肠外科学会会议的论文集。最近一次文献检索日期:1999年3月。
所有关于手术治疗成年人大便失禁(直肠脱垂手术除外)的随机或半随机试验。
两名评价者独立从文献中选择研究、提取数据并评估符合条件试验的方法学质量。三个主要结局指标为:失禁的改善或恶化、未实现完全控便、存在便急情况。
纳入了4项试验,总样本量为110名参与者。所有试验均排除了经肛门内超声检查发现肛门括约肌缺陷的女性。没有试验纳入非手术治疗组。两项试验(56名参与者)比较了三种盆底修复方法(前侧提肌成形术、肛后修复及其联合全盆底修复)。一项试验(30名参与者)评估了在全盆底修复基础上加做肛门括约肌折叠术。第四项试验(24名参与者)比较了新括约肌手术与全盆底修复。未发现主要结局指标存在差异,但数据较少且报告不一致。
已确定的相关试验数量少、样本量小以及存在其他方法学缺陷,严重限制了本综述对指导实践的有用性。无法确定或反驳不同手术方法之间临床上的重要差异。需要进行更大规模的严谨试验。