Mishriky N, Ibrahim Y A, Girgis A S, Fawzy N G
National Research Centre, Dokki, Cairo, Egypt.
Pharmazie. 2000 Apr;55(4):269-72.
2-Alkoxybenzo[h]quinoline-3-carbonitriles 2 were readily synthesized via Dimroth rearrangement of 2-amino-4-aryl-5,6-dihydro-4H-naphtho[1,2-b]pyran-3-carbonitriles 5 induced by ethanolic and methanolic KOH. Compounds 2 were also obtained by the reaction of 2-arylmethylidene-3,4-dihydro-1(2H)-naphthalenones 1 with malononitrile or of ylidenemalononitriles 4 with 1,2,3,4-tetrahydro-1-naphthalenone in ethanolic and methanolic KOH. The molluscicidal activity of the products towards Biomphalaria alexandrina snails was screened.
通过乙醇和甲醇氢氧化钾引发的2-氨基-4-芳基-5,6-二氢-4H-萘并[1,2-b]吡喃-3-腈5的Dimroth重排反应，可轻松合成2-烷氧基苯并[h]喹啉-3-腈2。化合物2也可通过2-芳基亚甲基-3,4-二氢-1(2H)-萘满酮1与丙二腈反应，或亚甲基丙二腈4与1,2,3,4-四氢-1-萘满酮在乙醇和甲醇氢氧化钾中反应得到。对产物针对埃及双脐螺的杀螺活性进行了筛选。
